F IELD T-l 

 Column 57 



The coding of the test compound's producing a pathological state is discussed in Divisions 7 

 and 11: In coding the test compound's production of a pathological state or process (Symbol 7 of 

 Field T-l), only those items of Field T-2 may be used which are of the second category described 

 above. 



When a pre-existing pathological state (coded in Fields E and T-2) is treated with the test 

 compound, Field T- 1 must be coded distinctively to indicate that the compound did not cause the 

 pathology. The following paragraphs describe this specific coding. 



If the entire disease, as is coded in Field E, responds to the treatment, Field T-2 is coded 

 with the appropriate symbol of the 17-- and 16-- series (the third of the categories of Field T-2 items) 

 and Field T-l is coded with Symbol 7. 



However, if only the pathological symptom of the general disease coded in Field E responds to 

 the treatment (this symptom being coded in Field T-2 as one of either the first or second categories of 

 Field T-2 items), Field T-l must be coded to indicate the effect on that particular pathological state 

 in returning it to normal ( curing it or stopping totally progress of a morphological change, even though 

 morphologic normality is not restored), returning it toward normal (improving the organism's condition 

 or restraining the progress of the pathology, but not curing it or not stopping totally progress of a 

 morphological change), or worsening the condition ( exacerbating the pathological state). The coding 

 of Field T-l to indicate a test compound's effect on a pathological symptom coded in Field T-2 depends 

 on the category of the Field T-2 terms to which the symptom belongs, as follows. 



If the pathology symptom is one of the second category of Field T-2 items (i. e. , an item 

 specifying pathology, such as apnea, anemia, etc. ) and if only the symptom coded in Field T-2 re- 

 sponded to the test compound, the test compound's effect is coded by Symbols 1, 2, or 3. Partial 

 reduction or arrest of progress but not a cure of the pathology symptom is coded by Symbol 2 of Field 

 T-l (reduction of dyspnea, pain, anemia, or atrophy, e.g.); cure, total reduction, or prevention of 

 the pathology symptom coded in Field T-2 or restoration of a pathologically totally suspended physi- 

 ological process, is coded by Symbol 3 of Field T-l ( cure of or prevention of abscess, inflammation, 

 or ventricular fibrillation, e. g. ; complete stoppage of necrosis; restoration of normal function from 

 states of sinus arrest or respiratory arrest, e. g. ); and exacerbation of the symptom is coded by 

 Symbol 1 ( increase of irritation, degeneration, edema, e. g. ). Note that if a test compound causes 

 (Symbol 7 of Field T-l) a pathological state indicated by one of these Field T-2 items of this second 

 category when it is administered to treat another pre-existing pathology, the pathology produced by 

 the compound is not to be coded as a symptom of a disease coded in Field E; instead, the host of the 

 general pathology is coded in Field E as the test organism and Field G is coded to indicate the fact 

 that the organism is in an unspecified pathological state in which the test compound causes the 

 pathological condition to be coded in Field T-2. 



If the pathology symptom is one of the first category of Field T-2 items (i. e. , an item describ- 

 ing a normal biological condition or process) and if only the symptom coded in Field T-2 responds to 

 the test compound, the test compound's effect must be coded by one of a group of symbols provided in 

 Field T-l especially for this purpose. These are the nine symbols indicated on the IBM punched card 

 by the 1 1 zone punch (Symbols J through R), J, K, and L being for curative effects, M, N, and for 

 effects in improving but not curing the symptoms, and P, Q, and R for effects in exacerbating the 

 symptom. Symbols P, Q, and R (exacerbation) are discussed in the next division. 



Of the first of these groups, Symbol J is used to indicate that the test compound increases the 

 biological process which is in a pathological state, and in increasing it, returns it to its normal state, 

 indicating that the process coded in Field T-2 had been in a pathologically depressed state when 

 treated. Symbol J would also be used to code the test compound's restoration of a pathologically 

 totally suspended physiological process. In the reverse, Symbol K is used to indicate that the test 

 compound decreases the biological process which is in a pathological state, and, in decreasing it, 

 returns it to its normal state, indicating that the process coded in Field T-2 has been at a patholog- 

 ically elevated level or accelerated pace. Symbol K would be used also to indicate that the test 

 compound stopped a pathological process initiated by (instead of increased by) a general pathology 

 coded in Field E. Symbol L is used to indicate that the test compound acts in some way other than to 

 increase (or restore) or decrease (or halt) a depressed (or abolished) or accelerated (or initiated) 

 process to return it to the normal state; for example, Symbol L would be used to indicate returning to 

 normal a physiological balance which had been pathologically altered (nitrogen balance, e. g. ) or 

 restoring to normal the general behavior of the organism (Symbol 55, e. g. ). 



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