FIELD T-l 

 Column 57 



In analogy to Symbols 2 and 3 which represent two categories of degree of decrease, partial 

 and absolute, two sets of symbols have been provided for coding actions on the pathology state coded 

 in Field T-2, one for complete return to normal (Symbols J, K, and L, described above) and one for 

 partial return to normal (Symbols M, N, and 0). 



Thus, Symbols M, N, and are used exactly as Symbols J, K, and L, except that they indicate 

 that the test compound has not succeeded in bringing the organism back completely to its normal state. 



When Symbols J, K, and L are used in Field T-l, evaluation in Field Y is made on the basis of 

 complete restoration of normalcy (analogous to the complete abolition of a biological condition or 

 process indicated by Symbol 3), as described in Division 8. When Symbols M, N, and are used, 

 evaluation is made on the basis of incomplete restoration of normalcy (analogous to the action indi- 

 cated by Symbols 1 and 2), i. e. , on the basis of degree of recovery as described in Divisions 6, 7, 

 and 8. 



17. S ymbols P, Q, and R; coding of the test compound's exacerbative action on a pathological 

 state or process, coded in Field T-2 as a symptom of a disease coded in Field E 



Reference should be made to the preceding division which discusses the coding of pathological 

 states treated by test compounds (Field E and T-2) and the coding in Field T-l to indicate the test 

 compound's action on those pathological states. The use of Symbols 1, 2, 3, J, K, L, M, N, and 

 for this purpose is explained in that division. 



Symbols P, Q, and R complete the three sets of symbols that are provided for coding test 

 compound's actions when the entry in Field T-2 is a term expressing a normal biological state or 

 physiological process (but a state made abnormal by a pathology coded in Field E). The two sets, 

 (1) J, K, and L and (2) M, N, and 0, are used to code the compound's ameliorative action, whereas 

 Symbols P, Q, and R are used to code the compound's exacerbative action. While the use of Symbols 

 P, 0, and R may be relatively infrequent, they are included to present the total concept of coding 

 Field T-l under the circumstances of Field T-2 being coded with a pathological symptom indicated 

 only as a normal state or process. 



Symbol P is used when the test compound decreases the biological process which is in a 

 pathological state and, in decreasing it, exacerbates the state, indicating that the process coded in 

 Field T-2 had been in a pathologically depressed state when treated. 



Symbol is used when the test compound increases the biological process which is in a 

 pathological state and, in increasing it, exacerbates the state, indicating that the process coded in 

 Field T-2 had been in a pathologically elevated level or accelerated pace when treatment was admin- 

 istered. 



Symbol R is used when the test compound has made further aberrant an organism's activity or 

 physiological balance which had been in a disturbed state at the time of administration; e. g. , a 

 disturbed nitrogen balance or abnormal behavior. Thus, Symbol R used in Field T-l with Symbol 55 in 

 Field T-2, for example, would indicate that the organism's behavior which had been abnormal at the 

 time of administration was made even more abnormal (i. e. , exacerbated) by the administration of the 

 test compound, an exacerbative .action that would be inadequately expressed by the terms "increase'' 

 or "decrease". 



18. Coding of the test compound's failure to produce a response when the test was not made for 

 specific action on any specific, named biological state or physiological process 



Coding of the compound's failure to produce a response (negative data) is discussed in 

 Division 1 of the Specific Directions and Explanations for Fields W, X, and Y. Most frequently, an 

 experiment is designed with the objective of determining a compound's ability to perform one or more 

 stated, specific actions. When the compound proves inactive with respect to a specific action, 

 coding of that inactivity is properly restricted to that specific action, which means that Fields T-l 

 and T-2 are to be coded to indicate the action and biological state or process with which the test was 

 concerned and the inactivity of the test compound with respect to that specific action and biological 

 state or process is indicated by appropriate coding in Fields W, X, and Y. 



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