FIELD T-I 

 Column 57 



Occasionally, however, negative test results are expressed as a generality; i. e. , the author 

 merely indicates that the test compound caused "no response". These are not unimportant data, even 

 though it makes no reference to any specific action or specific biological state or process. To make 

 possible coding this indefinite expression, a special symbol is provided in Field T-l, Symbol 0, which 

 indicates that no biological action (increase, decrease, initiation, etc. ) by the test compound was 

 detected in a test for which the alteration of no specific biological state or physiological process 

 was being sought. 



Since the expression, "no response", entails no specific biological state or process, a special 

 coding provision is also made for Field T-2, Symbol 1. This symbol in Field T-2 means essentially 

 that none of the biological states or processes indicated by other Field T-2 symbols were affected by 

 the test compound. 



Thus, Symbol of Field T-l must never be used when a symbol other than 1 is in Field T-2 

 and, in the reverse, when Symbol is in Field T-l, only Symbol 1 can be used in Field T-2. All other 

 negative data (involving specific action on specific biological states or processes) must be indi- 

 cated by appropriate coding in Fields W, X, and Y, as explained in Specific Directions and Explanations 

 for those fields (Division 1, Subdivision B). 



When Symbol is used in Field T-l and Symbol 1 in Field T-2, Field W must be coded with 

 Symbol L or M, Field X with Symbol 01 (or possibly Symbol 02), and Field Y with Symbol 1. 



Note that when a specific biological state or condition is named as being one for which the 

 test compound is administered to affect and when the test compound might affect that biological 

 state or process in either of two ways (increase or decrease, antagonism or synergism of a secondary 

 compound's action on it) and it caused ne ither action, Symbol should never be used in Field T-l 

 to code the inactivity on this specific biological state or process. Instead, Field T-l is double- 

 coded with both symbols (indicating both possible actions the test compound might have had, 1 and 2, 

 or 8 and 9), Field T-2 is coded with the specific biological state or process, and Fields W, X, and Y 

 are coded to indicate the negative activity. 



19. Symbols available for expansion of Field T-l 



Symbols B, H, and I are available for actions other than those of the present list of Field T-l. 

 Symbol B was assigned earlier to an action described as "summation", but because of a general lack 

 of use and misunderstanding of the meaning and use of the term, it has been omitted in the present 

 list, freeing Symbol B for another use. Symbols D, E, F, and G may eventually be found to be used 

 so infrequently that their present definitions could be replaced by others more useful. 



Having assigned to the IBM zone punch the definition "no effect" (when no specific biolog- 

 ical state, character, or process had been tested for its response to the test compound), Symbols S 

 through Z are not available. Since the actions already included in the list have been adequate for all 

 data encountered by the CBCC, it has not seemed probable that Symbols S through Z would be needed. 



20. File of coded biology data arranged according to symbols for test compound specific actions 



The CBCC has established no separate file of biology data arranged according to the actions 

 coded in Field T-l. The most probable use of such a file would be in assembling antagonism or 

 synergism data, but it has so far been more practical to depend on the special file arranged by Field 

 D entries (the secondary compound file), performing a machine sort for synergism or antagonism 

 coded in Field T-l, rather than maintaining a separate Field T-l file which would necessarily be as 

 large as the principal file arranged by CBCC Chemical serial number, due to every line demanding an 

 entry in the field. 



21. Double coding in Field T-l 



Two code entries are never permitted in Field T-l, with the one exception explained in the 

 section dealing with coding of no effect on a specific biological state, character, or process coded 

 in Field T-2 when the compound might have caused effect in either direction (when both Symbols 

 1 and 2 are coded in Field T-l and Fields X and Y are coded to indicate the failure to cause either 

 an increase or decrease); refer to Division 18. When both Symbols 1 and 2 are coded in Field T-l, 

 both are punched on the same IBM card in Column 57. 



- 132 - 



