FIELD T-2 

 Columns 58, 59, 60, and 61 



regeneration, Symbol 272; atrophy, Symbol 411; tumor growth, Symbol 44; excretion, Symbol series FF--) 

 which the test compound is tested to affect or cause. Whether the test compound is tested to affect or 

 cause the state, quality, or process coded in Field T-2 is indicated by the coding in Field T-l. 



If all the coding fields are considered in rank of importance, it is Field T-2 and Field T-l that 

 must be given first place along with the code identification of the compound tested. Every line coded 

 must have an entry in Fields T-l and T-2. Next in rank are the identification of the biological system 

 tested (Field E and frequently Field J) and evaluation of the test results (Fields W, X, and Y), both of 

 which the CBCC also considers essential information for every code line. 



Specific Directions and Explanations 



1. Use of symbols with fewer than four units 



When a symbol of Field T-2 has only one unit, it is to be coded in Column 58 and the remaining 

 three columns must be cross-hatched, as in the case of uncoded columns of Field E and Field J. Simi- 

 larly, if the symbol has only two or three units, the final two columns or the final column of the field 

 must be cross-hatched. This provides subsequent assurance that the coder did not err in omission, but 

 intended to use only the first one, two, or three columns, as the case may be. 



2. Use of Symbol I; gross response 



All of the Field T-2 items whose symbols begin with 1 are described as being "gross effects" 

 which do not fit precisely with any other of the established categories of the field. 



When the number 1 is used alone as a symbol (in Column 58), it is to code a generality , referring 

 to no specific biological state or process nor even a specific type of biological state or process (fre- 

 quently, if the response is of a specific type , it can be indicated by a symbol of Field T-3, using 

 Symbol 14 in Field T-2); consequently, Symbol 1 is never used except with negative data which are 

 described as such a generality. ( Positive data expressed as this generality would not be coded by the 

 CBCC; for example, a statement such as, "the test compound produced response", with no indication 

 what the response, or type of response, was, would be meaningless and would not be coded. ) In other 

 words, only when an author states that "no response" occurred and does not specify that one or another 

 specific biological state or process or specific type of response was not affected or caused, can Symbol 1 

 be used. It is used only with Symbol in Field T-l which is itself restricted to this one use with Sym- 

 bol 1 of Field T-2. (See Division 18 of the Specific Directions and Explanations of Field T-l. ) 



3. Coding of DEATH of organisms as a response to a test compound; restrictions on the use of 

 Symbols 11, 111, and 112 for coding death 



Those specific responses that can be considered as general toxic responses and which do not 

 conveniently fit with other pathology categories of Field T-l are coded by the symbol series 11-. 



The first of these responses is death which is somewhat unique in the list of Field T-2 items in 

 that three definitions and three symbols have been assigned to it, each differing in terms of conditions 

 leading to death. The test compound's potency for inducing death is such important information that 

 Field T-2 has been given certain distinguishing functions it ordinarily doesn't have, to which end have 

 been provided the three definitions for death; the three definitions permit the field to distinguish certain 

 information about the dose and its administration. For example, the duration of administration is given 

 a gross distinction by Symbol 112 which bears in its definition the stipulation that administration was 

 continuous for over 24 hours. In contrast, Symbols 11 and 111 both differ from Symbol 112 in that, by 

 their definitions, administration is either by a single dose or, if continuous or multiple, can be no more 

 than 24 hours. Such distinction is ordinarily exclusively the function of Field P and, even in the case 

 of using Symbols 11, 111, and 112, Field P is used to indicate the duration of administration more 

 precisely than >24 hours, 24 hours, or <24 hours. Such minor distinctions made by Symbol 112, as 

 indicated by this example (frequency of administration, duration of administration, or time to kill) are 

 not actually of much significance as a means of sorting for coded data, since that particular information 

 is coded in special fields (Fields O, P, and U). However, by the collective distinctions made in 

 frequency of administration, duration of administration, and killing time. Symbol 112 is useful in 



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