FIELD T-Z 

 Columns 58, 59, 60, and 61 



Occasionally, data are encountered in which the author expresses an effect only in terms of 

 one of the general categories of response described by Field T-3 items. This does not necessarily 

 represent data that are too vague or general to be coded; to the contrary, it most frequently is a precise 

 description of response even though in a somewhat collective sense. For example, to indicate only 

 that a test compound has proved to be sympathomimetic may be assumed to mean that the compound has 

 been demonstrated to bring about all the specific effects typical of that category of drugs. 



The CBCC codes such information by entering in Field T-3 the code symbol for the general 

 category of chemical action and by use of a special symbol in Field T-2 which has no meaning other 

 than to refer the interpreter from Field T-2 to Field T-3. This is Symbol 14 which is used only with 

 Symbol 7 of Field T-l to mean that the test compound causes a general effect as indicated by the coding 

 in Field T-3. 



Symbol 14 is not to be used by a coder merely because a specific biological state or process 

 has not yet been included in the Field T-2 list; in this case, Field T-2 will need to be expanded by the 

 Center's adding that item to Field T-2 and assigning it a symbol. Also, it will be understood that 

 Symbol 14 can never be used without an entry in Field T-3. 



12. Symbol 15; coding of a response involving an unspecified normal functioning of a specific 

 anatomical part of the test organism 



Occasionally, test results are expressed by an author only by stating that the normal function 

 of an anatomical part has been affected (interrupted, increased, decreased) by the test compound (or 

 by a secondary compound, which effect is itself affected by the test compound). It is not always 

 certain, by such a general statement, which normal function of the anatomical part has been affected 

 (if the part is known to have more than one specific normal function) or whether all its functions are 

 affected. Although it is not frequent that the coder can not determine what specific process has been 

 affected by having the anatomical part designated by the author, a means of coding a non- specified 

 process of a specified anatomical part is needed. 



Symbol 15 is provided in Field T-2 to indicate a normal process unspecified except by reference 

 to Field H-l or I where the organ or tissue is named whose normal (but unspecified) function has been 

 affected by the test compound as indicated by coding in Field T-l. 



13. Symbols of the 16-- and 17-- series; coding of the EFFECT OF test compounds ON basic 

 pathological states (Field E) of the biological organism (in contrast to coding of production 

 of pathological states [Field T-2] BY the test compound); only Symbol 7 of Field T-l may be 

 used with symbols of the 16-- and I7-- series; symbols of the 16-- and 17-- series are 

 used to code chemical effects on any infectious or non-infectious pathology EXCEPT TUMORS 



Compounds are very frequently administered to test their effects on pathological states of an 

 organism. Field E is used to code the specific pathology treated, the symbols for pathology being 

 listed as the Pathology Code section of Field E. 



Coding of pathology is discussed in considerable detail in the section of the Key dealing with 

 the Pathology Code of Field E. Whenever a compound is administered to test its therapeutic (or 

 exacerbative) effect on a specific pathological state, that state must be coded in Field E. In other 

 words, if a compound is tested therapeutically, Field E is never coded with the diseased organism 

 treated (host), but only with the taxonomic symbol for the pathogen causing the infectious disease or 

 the Pathology Code symbol for the non- infectious disease; the diseased organism is coded in Field J. 

 Under these circumstances. Fields T-l and T-2 are coded in one of two ways. They may be coded to 

 indicate the effect the compound has on the disease In general in Field E, using any symbols of the 16-- 

 or 17-- series in Field T-2 and Symbol 7 in Field T-l . They may, however, be coded to indicate the 

 effect the test compound has on any one particular symptom of the disease in Field E, using the symbol 

 for the specific pathology symptom in Field T-2 and any symbol other than Symbol 7 in Field T-l (though 

 Field T-l Symbols 6, D, E, F, or G would not be appropriate for indicating a chemical action on a 

 pathological symptom). 



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