FIELD T-Z 

 Columns 58, 59, 60, and 61 



Excretion, secretion, etc. , of the normal secondary compound 



FC--: For Symbol FC--, the term "normal" is used to describe (1) any specific chemical normally 

 a component of the organism as a whole, (2) any specific chemical normally consumed or 

 absorbed by the organism and contributing beneficially to its normal activities, or (3) any 

 specific chemical normally a metabolic product of the organism. This normal material 

 may be thrown off through excretory or exocrine secretory organs unaltered by those organs 

 or it may be chemically altered by the organs before being discharged as a normal compo- 

 nent of the organ's product. Thus, loss or discard of any material is coded by Symbols 

 FC-- and FF--, the distinction being that Symbol FF-- denotes the discard of material 

 FOREIGN to the excretory path (or exocrine path), while Symbol FC-- denotes discard of 

 materials NORMAL to the path. (See also Division 27. ) Symbol FC--, like Symbol FF--, 

 is intended only for test compound effects on LOSS or DISCARD of materials. In partic- 

 ular, the symbol is not intended for test compound effects on endocrine secretory activ- 

 ities producing specific chemical products normally used internally for regulatory 

 purposes, for which Symbol FE (with an asterisk in Column 61) or F85- would be 

 used, with the secretory organ coded in Field H-l. However, for test compound effects 

 on any discard of normal hormones through normal paths, use Symbol FC5- with the 

 excretory organ or exo crine gland in Field H-l and the specific hormone in Field D. (For 

 effects on discard of hormones foreign to the organism or of the organism's own hormones 

 over abnormal paths, use Symbol FF-5. ) If any material being discarded is a normal 

 material chemically altered or a normal product produced by chemical alteration and if the 

 test compound effect is precisely on the chemical alteration by the excretory organ or exo- 

 crine gland, use Symbol F8-- or FE--, instead of Symbol FC--. Code in Fields H-l 

 and/or I the excretory organ or tissue or exocrine gland. Since Symbol FC-- is used only 

 for discard of normal materials, it can not be combined with Symbol --B to make the 

 composite Symbol FCB. Only Symbols 1, 2, 3, 8, 9, A, or C of Field T- 1 may be used 

 with Symbol FC--. Symbol FC (with no coding in Column 60 or 61) can be used to code 

 the general normal excretory or secretory function (of an organ or tissue in Fields H-l 

 and/or I, through which normal materials are discarded) which function can be affected 

 by the test compound. 



Ability to permeate or penetrate 



FG--: Use Symbol FG-- when the ability of the specific secondary compound to permeate or 

 penetrate is affected by the test compound. When the test compound effect is on the 

 membrane, altering its character rather than the penetrating ability of the secondary 

 compound, use Symbol 842. Symbol --B cannot be combined with Symbol FG-- to make 

 the composite Symbol FGB, since the test compound can not cause or affect its own 

 ability to penetrate or permeate; the test compound's ability to penetrate or permeate is 

 equivalent to its capacity for being absorbed and is coded by Symbol FBB. 



Incorporation of the test compound 



FH--: Use Symbol FH-- to code the test compound per se being incorporated into the structure 

 of a compound synthesized by the test organism (the test compound ordinarily being a 

 labelled compound or element, detectable after its being used by the organism in chemo- 

 synthesis). In coding this effect on the test compound, only Symbol 7 is used in Field 

 T-l, just as in the case of coding specific chemical alterations with symbols of the FE-- 

 series. To code the test compound's influence on the similar incorporation of a secondary 

 compound into one of the organism's constituents, use Symbol 8, 9, A, or C of Field T-l 

 and code the secondary compound in Field D (writing in Field T-2 the specific identity of 

 the compound which is coded only as to type in Field T-2). This is a more specific cod- 

 ing than to indicate only that the test compound can substitute (Symbol A of Field T-l) 

 for the material normally used for synthesis of the compound (Symbol F42- of Field T-2). 

 Note that Symbol --B would never be combined with Symbol FH-- to make the composite 

 Symbol FHB. This is because the stipulation of the test compound is made by Symbol FH-- 

 itself when used with Symbol 7 of Field T-l; appending Symbol --B to it would be erro- 

 neous (i. e. , the statement, "the test compound is incorporated into the test compound", 

 is meaningless). 



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