FIELD T-2 

 Columns 58, 59, 60, and 61 



Withdrawal of the secondary compound (or test compound) 



FI--: Code in Fields H-l and/or I the site of withdrawal. (Use Symbol FA-- to code deposit 

 or storage of a compound. ) Use Symbol 7, 1, 2, or 3 (or 8, 9, A, or C) of Field T-l 

 with Symbol FI-- to code the test compound's causing withdrawal or speeding or slowing 

 a normal withdrawal or a withdrawal caused or affected by secondary compounds. Since 

 the stored or concentrated test compound would not itself cause its withdrawal, nor 

 would administration of more of the test compound be apt to cause the withdrawal from 

 a deposit of the test compound, Symbol FI-- is not to be combined with Symbol --B to 

 make the composite Symbol FIB, except when Field E is coded with a pathology, one of 

 whose symptoms is the withdrawal of the test compound from a site of normal deposit. 

 This effect on the test compound by pathology can be coded as justifiably as can be 

 coded the alteration of the test compound by the normal organism. 



26. Symbols of the FE-- series; alteration of the test compound, secondary compound, or third 

 compound 



Symbols of the FE-- series are unique in that they do not represent biological states or proc- 

 esses which the test compound can cause or affect, but, on the contrary, represent an effect on the 

 test compound (or a secondary compound or a third compound) by the test organism. (Of the other sym- 

 bols of Field T-2, only Symbols F8B, FAB, FBB, FH--, and FIB fall within this definition. ) In the case 

 of the FE-- series, the effect is chemical alteration by the normal test organism or a pathology coded 

 in Field E. 



With symbols of the FE-- series, the coding of Fields T-l, T-2, and D is according to the 

 following pattern: 



(A) Alteration of the test compound : Only Field T-l Symbol 7 can be used, being interpreted 

 under these conditions as "undergoes" (e.g., "the test compound undergoes oxidation"). 

 The specific alteration is coded in Field T-2 and the by-product, if known, is coded in 

 Field D. 



(B) Effect of the test compound on alteration of a secondary compound: Field T-l Symbol 1, 

 2, or 3 can be used; also, Field T-l Symbol 7 can be used to indicate a test compound's 

 being essential for the alteration of the secondary compound. The secondary compound's 

 specific alteration which is affected by the test compound is coded in Field T-2 and, in 

 addition, Symbol * is placed in Column 61. The secondary compound whose alteration 

 is affected is coded in Field D. The by-product of the secondary compound's alteration 

 is written, not coded, in Field T-2. 



(C) Effect of the test compound on a secondary compound's effect on the alteration of a 

 third compound : Only Field T-l Symbol 8, 9, A, or C can be used. The third compound's 

 specific alteration which is affected by the secondary compound is coded in Field T-2 

 and, in addition, Symbol * is placed in Column 61. The secondary compound antagonized, 

 synergized, simulated, or whose action is additive with the test compound, is coded in 

 Field D. The identities of (1) the third compound whose alteration is affected by the 

 secondary compound and (2) the by-product of the third compound's alteration are written, 

 not coded, in Field T-2. 



Fields H-l and I are always used to code organs or tissues affected by the test compound. How- 

 ever, when a compound's alteration by the test organism is coded (symbols of the FE-- series), Fields 

 H-l and I are coded to conform to this particular type of information. Under this situation, then, Fields 

 H-l and I should be coded only with the site of alteration, if known (i. e. , with the organ or tissue of 

 the organism causing the compound's alteration). 



When an alteration of the test compound is demonstrated to be caused by an enzyme, the infor- 

 mation is never coded by the CBCC. The ruling evolved, because the CBCC procedure for coding infor- 

 mation from studies on specific enzymes involves identifying the specific enzyme in Field T-2, by 

 coding there its specific symbol from the Enzyme Code. In doing this, the specific typical action of the 

 enzyme is indicated by the name of the enzyme. (Consult Division 22 and the Enzyme Code. ) When 

 using Field T-2 in this way for coding enzymes, the use of Field T-l has been patterned so that none 



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