FIELD T-3 

 Columns 62, 63, and 64 



by test compounds into two categories, an undesired effect (when a non- toxic compound is wanted for 

 purposes such as therapy) and an intended effect (when a toxic compound is wanted for population con- 

 trol of organisms). It is only for the second of these two categories that Field T-3 is coded with 

 symbols of the 1-- series; the distinction is made by not coding Field T-3 when a lethal action coded 

 in Field T-2 is undesired. 



This might have been accomplished by providing only a single symbol in Field T-3 which would 

 have indicated that the lethal information was of the category as described above (death being intended 

 and desired) and that it was for the test organism coded in Field E. However, the CBCC has provided 

 a list of specific categories and coding of Field T-3 should conform to the categories' descriptions in 

 the Code (herbicide, rodenticide, air-disinfecting agent, etc. ). 



Included in this series are the two terms, repellent and attractant, which were once coded in 

 Field T-2 as being special states of the test organism brought about by the test compound (states of 

 repulsion and attraction). They are now included in this Field T-3 symbol series on the basis of the 

 fact that the qualities of attractiveness or repellency qualify a test compound for controlling organisms 

 as well as its lethal qualities. When either repellent or attractant (Symbol 116 or 117) is coded in 

 Field T-3, Field T-2 is coded only with Symbol 14. 



As indicated above, Field T-3 is coded with a symbol of the 1-- series only when death of the 

 test organism (or repellency or attraction of the test organism) is the desired response; if the compound 

 tested does not cause death, attraction, or repulsion at the dose administered, when death, attraction, 

 or repulsion is the objective of the test, Field T-3 should nevertheless be coded with the appropriate 

 symbol of the 1-- series and evaluation in Field Y should be based on the compound's ability to kill, 

 attract, or repel (evaluated as negative in Field Y). Furthermore, in such tests in which death, 

 repellency, or attraction is the desired response and the test compound proves to produce an effect 

 opposite to the desired response (increase of infestation instead of death, attraction instead of 

 repellency, repellency instead of attraction), two code lines should be prepared, one with Field T-3 

 coded to indicate the death, repellency, or attraction desired and evaluated negatively and a second 

 line with Field T-3 either not coded or coded with the opposing effect actually produced and with 

 evaluation based on that action produced. 



2. Symbols of the 2-- series; the general pharmacological category of test compounds' specific 

 physiological effects; the pharmacological use for which the test compound is evaluated . 



The explanation of the use for terms of the 1-- symbol series can be applied to terms of the 

 2-- symbol series. When any test result indicates that the compound tested is candidate for being 

 classed in one of the categories represented by symbols of the 2-- series, Field T-3 should be coded 

 with one of those symbols. When a test method is specifically designed to demonstrate a compound's 

 ability to cause one of the effects of symbol series 2--, Field T-3 should be coded with that category 

 of effect to indicate its being evaluated on that basis, whether the test compound produced the effect 

 or not. 



3. Symbols 272 and 273; carcinostatic and carcinoclastic compounds 



Symbol 272 implies that a tumor affected by the test compound is retarded but not that it 

 regresses. Only Symbol 273 is used to indicate the regression of a tumor. 



Symbol 273 is used when the specific effect coded in Fields T- 1 and T-2 indicates that the 

 compound produces a destructive effect on a tumor as judged by loss of transplantability or by 

 regression attributable to action of the test compound. 



4. Choice of Field T-3 symbols when either of two (or more) might describe the compound 



In cases when either of two items might be appropriate (e. g. , anti-rheumatic, Symbol 211, and 

 adrenal-corticoid, Symbol 240), the coder must make the most appropriate choice, depending on the 

 nature of the test or the emphasis of the author's description, rather than prepare two code lines. 



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