FIELD V 

 Column 67 



different criteria and only one evaluation criterion is possible for each code line; if both evaluations 

 are to be coded (intensity of response after 10 minutes and maximum intensity of response), two code 

 lines will be necessary in each of which will be coded the appropriate time to evaluation. 



In the case of those tests evaluated by "time to specific action other than death" (Criterion 10 

 or 58) or "killing time" (Criterion 11 or 59), evaluation is necessarily at the point of beginning of the 

 specific action or at the point of death. The "time to specific action" or "killing time" is therefore 

 identical to "time to evaluation" and Fields U and V would be coded with the same values (though not 

 with the same code symbols). Refer to Division 3 of the Specific Directions and Explanations for Field U. 



On the other hand, tests evaluated by "alteration of survival time" (Criterion 12 or 57) or 

 "duration of action" (Criterion 13 or 54) have periods of "time to evaluation" (Field V) quite different 

 from the periods coded in Field U. The "time to evaluation" of an alteration-of- survival-time test 

 begins with administration of the test compound and ends at the death of the treated organism, whereas 

 the coding in Field U represents a period which is the difference between the survival times of the 

 treated and untreated organisms. The "time to evaluation" of a dura tion-of- action test begins with 

 administration of the test compound and ends at the point of the disappearance of the action, whereas 

 the coding in Field U is a period beginning at the first appearance of the action and ending at its 

 disappearance. 



2. Coding in Field V when the test compound produces no biological response 



If the test compound produces no response, or fails to produce a specific response for which 

 it is being tested (coded in Fields T- 1 and T-2), the entire period of observation is coded in Field V. 



3. Tests for persistence of activity of a residue of the test compound; coding in Field V 



Reference should be made to the explanation of persistence of activity of residue tests, in 

 Division 4 of the Specific Directions and Explanations of Field U. In coding the data of the first 

 exposure to the residue, Field V should be coded with the period beginning at the time the test 

 organism contacts the residue ( not beginning at the time of application of the residue to the substrate) 

 and ending with the evaluation of the response of the test organism (not ending with the evaluation of 

 the test compound's persistence as a residue). 



4. Prophylaxis studies; coding in Field V 



In coding evaluation time for studies of prophylaxis, the beginning of the period to be coded 

 in Field V is the time at which the first dose is administered to .the host, even though invading 

 organisms are not yet present. 



5. Coding in Field V when the exact time of evaluation is not known, but an approximate time of 

 evaluation is known 



Frequently a test procedure will not allow continuous observation, or continuous observation 

 is inconvenient, and, during an interval between two observations, peak action or final action occurs. 

 A common example is the death of an organism (or the death of the last of a group of organisms killed 

 in the test) which occurs sometimes between two observations. Since the exact time of the death can 

 not be known, the exact end of a "time to evaluation" period is unknown. In these cases, the CBCC 

 has coded in Field V a time period ending with the first observation after the death or peak action. 



6. Symbols available 



All available symbols have been assigned definitions in this field. 



7. File of IBM punched cards 



No file of IBM punched cards has been established, arranged by code entries in Field V. 



169 - 



