FIELDS W, X, and Y 



Columns 68; 69 and 



70; and 71 



EVALUATIONS OF THE BIOLOGICAL RESPONSE 

 TO THE TEST COMPOUND 



Organization 



These three fields, W, X, and Y, represent collectively a unit for coding one aspect of a 

 chemical- biological test, in the same way that Fields M, N, 0, and P make a unit for coding dosage 

 and Fields T-l, T-2, and T-3 make a unit for coding biological response of such a test. Fields W, X, 

 and Y are used to code a statement of evaluation of the test results, indicating (1) whether the response 

 did or did not occur, (2) if the response did occur, to what degree or intensity, (3) if the response did 

 not occur, whether the test demonstrated that the chemical CAN not cause the response, and (4) the 

 test compound's potency for causing the response (or its safety in not causing a response that is 

 pernicious), considering the quantity needed. These are all discussed in detail in the following 

 sections on General Use and Specific Directions and Explanations. 



Field W , a single-column field (Column 68), has been given eight symbols for the use described 

 in the next section, General Use. Symbols J, K, L, M, N, 0, P, and Q were chosen because the 12 

 zone punch (Symbol *) was given a meaning distinct from the other symbols (prohibiting the use of 

 Symbols A through I) and because Field W had been for a different coding purpose for which Symbols 1 

 through 9 had been used. This former use of Field W is described in the section on General Use. 

 Thus, Symbols J through Q were used rather than Symbols 1 through 8 to avoid confusion with the 

 earlier CBCC use of the numerical symbols by which considerable data had been coded, punched, and 

 filed. (In a newly started coding project, these symbols might well be numerical rather than J through Q. 



Fields X and Y have been organized in the Code so that each symbol for Field X is accompanied 

 by Field Y symbols which have definitions specifically related to that Field X symbol and which must be 

 used with that Field X symbol. 



Field X is a two-column field (Columns 69 and 70). Because there is generally advantage in 

 similar items being listed together and in having these similar items represented by code symbols of 

 related order, the criteria have been organized into several groups which can be distinguished by 

 examining the Code. One example of criteria having an evaluating characteristic in common consists 

 of criteria basing evaluations on time values alone, Criteria 10, 11, 12, and 13 (coded as Symbols 10, 

 11, 12, and 13). Other groups are as follows: Authors' expressions of evaluation (01 and 02), com- 

 parisons to a compound which the author has considered sufficiently standard to serve as a reference for 

 activity of a test compound (03 and 04), special indexes for evaluation (14, 15, 16, 17, 18, and 19), dos- 

 age criteria basing evaluation on dosage size alone (20, 21, and 22), special criteria for specific actions 

 (30 and 31), those criteria whose evaluation determinations include consideration of dosage values or 

 time values correlated with variation in individuals of a group (51, 52, 53, 54, 55, 57, 58, and 59), 

 and criteria basing evaluation solely on intensity of response , which may be in terms of the percentage 

 of individuals in a group responding, (61 and 62). Field X items have been limited to numerical symbols, 

 because it is more practical to do so when the items are few enough to permit it. This is because the 

 IBM processing is always more simple when zone punches need not be used for forming letter symbols. 



Field Y , a single column field (Column 71), is ordinarily limited to numerical symbols (the zone 

 punch and Symbols 1 through 9). Thus, as many as ten levels of evaluation of positive activity may be 

 coded. The CBCC considers this as providing evaluation grading to, or beyond, a maximum degree of 

 significance. Inasmuch as evaluation is usually restricted to numerical symbols and the zone punch, 

 the 11 and 12 zone punches were available in Field Y for a special use. This use is described in the 

 section describing the Grid, Division 24 of the Specific Directions and Explanations. 



In the case of three criteria of Field X, Criteria 01, 02, and 62, Symbol 1 is reserved for 

 expressing negative data exclusively (see Division 1, Subdivision B, of the Specific Directions and 

 Explanations). Since, with negative data, the 11 or 12 zone punches would never be used (as explained 

 later), the two letters A and J (formed by IBM combination of Symbol 1 plus the 12 or 1 1 zone punch, 

 respectively) are permitted as symbols for Field Y in the case of those three criteria. This does not 

 represent a retrieval problem relative to the 11 and 12 zone punches, because mechanical sorting for 



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