FIELDS W, X, and Y 



Columns 68; 69 and 



70; and 71 



Specific Directions and Explanations 



1. Coding of negative data; i. e. , coding of failure of the test compound to produce a given 

 response or to produce any response. Use of Field X Criteria 01, 02, and 62, with Symbol 1 

 in Field Y and Symbol J or K in Field W 



A. "No response of any kind", when the test did not have as an objective the determination 

 of some specific response 



In a given test, the test compound may produce no detected biological response of any nature; 

 the organism and its living functions remain unaltered. The results of such a test may be expressed 

 by the author no more specifically. 



The expression, "no response of any kind", occurs comparatively infrequently. This is largely 

 because chemical tests are usually performed for production of a specific response, in which case, 

 regardless of whether the chemical did or did not produce any other response, the evaluation is ex- 

 pressed in terms of the chemical's performance in producing or not producing that specific response 

 which is coded in Field T, as explained in Divisions IB and 2, below. 



However, to permit coding the unspecific expression, "no response of any kind", Fields T- 1 

 and T-2 are coded by specially provided symbols, Symbol of Field T- 1 and Symbol 1 of Field T-2. 

 (See Division 18 of Field T-l. ) While this codes the fundamental fact of "no response of any kind", 

 CBCC coding procedure demands nevertheless that code evaluation be entered in the area especially 

 assigned for evaluation, Fields W, X, and Y. Regardless of which Criterion is used in Field X (it will 

 probably usually be Criterion 01, though it could conceivably be by Criterion 02), Field Y must be 

 coded with Symbol 1 and Field W must be coded with Symbol J (or Symbol K, if the test compound were 

 known to have been administered at its maximum tolerated level). 



B. "No response" or "no effect", relative to a SPECIFIC response for which the chemical 

 was being tested 



When a test is designed to determine a compound's unknown ability to produce a specific 

 response, the result of the test may be negative relative to that specific response; in other words, 

 certain compounds will be discovered to be ineffective in producing that specific desired response, 

 regardless of what other responses they may cause. The author will express such negative results in 

 terms of the specific response; for example, "the compound did not cause death", "did not have a 

 repressive action on a disease", "did not increase cardiac rate", "did not decrease cardiac rate", 

 or "had no effect on cardiac rate; i. e. , neither increased nor decreased cardiac rate", etc. The 

 CBCC codes these expressions literally; Field T-l would be coded with Symbol 7 ("causes" or "has"), 

 Symbol 1 ("increases"), Symbol 2 ("decreases"), Symbol 1 and 2 in the same line ("increases and 

 decreases"; i. e. , "an effect in either direction on the rate of the specific normal activity"), etc. , 

 and Field T-2 would be coded with Symbol 11 ("death"), Symbol 175 ("repressive action"), Symbol CI 

 ("cardiac rate"), etc. 



To record that the specific response coded in Field T was not produced, Field X must be coded 

 with Criterion 01, 02, or 62 and Field Y must be coded with Symbol 1. (Note the definitions and 

 discussion of the terms "no response", "inactive", "negative response", etc. , in Division 6. ) 

 Field W must be coded with Symbol J (or Symbol K, if the chemical were known to have been administered 

 at the maximum tolerated level). 



2. Coding of positive data; 1. e. , coding the test compound's demonstrated PRODUCTION of a 

 specific response; use of symbols of Fields X and Y (except Symbol 1 of Field Y with 

 Criterion 01, 02, or 62) and use of Symbols L, M, N, 0, and P of Field W 



When the results of a test are positive, the author will necessarily identify the specific response 

 which must be coded in Field T. This is merely to point out that positive data are never reported as "the 

 rest compound produced a response" without specifying what the response was, in the way that negative 

 data are sometimes reported as "no response" (see Division 1, Sub-division A) without specifying a 

 particular response that was not produced. 



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