FIELDS W, X, and Y 

 Columns 68; 69 and 

 7 0; and 71 



For any one specific response positively produced, a separate biology code line must be con- 

 structed, with the specific response coded in Field T. (The CBCC coding policy often limits the 

 number of specific responses and, correspondingly, the number of code lines to be coded from certain 

 tests characteristically resulting in a complex of many specific responses, as explained in Field T-2, 

 Specific Directions and Explanations, Division 8. ) 



In this code line for positive data, in which Field T is coded to represent a specific response, 

 Fields W, X, and Y must be coded to relate only to that one specific response which was actually 

 produced by the test compound. Field X may be coded with any appropriate Criterion, including 

 Criterion 01, 02, or 62. Field Y may be coded with any of Symbols or 1 through 9, according to the 

 Criterion used, as indicated in the Code- -EXCEPT that Symbol 1 may never be used with Criterion 01, 

 02, or 62, if the response were actually produced, since this coding is reserved to indicate negative 

 results only (i. e. , "no response"), as explained in Division 1. Symbol 1 with any Criterion other 

 than Criterion 01, 02, or 62 is defined and can be interpreted as "positive response, but low in 

 effectiveness", never as "no response". 



Field W must be coded with one of the five symbols, L, M, N, 0, or P, according to what the test 

 demonstrated about the potency of the compound (minimum dose and maximum response intensity) for 

 causing the biological response. (1) If the dose administered is not known to be the minimum dose (below 

 the max. tol. dose) producing maximum response, use Symbol L, M, or N; (2) if the response has been 

 demonstrated to be the maximum which the compound is capable of producing (barring death or limiting 

 toxicity) and the dose is the minimum needed to produce it, use Symbol 0; (3) if the response has been 

 demonstrated to be the maximum which the compound is capable of producing (barring death or limiting 

 toxicity), but the dose administered is not known to be minimum needed to cause that maximum response, 

 use Symbol M or N; (4) if the response has not been demonstrated to be the maximum which the compound 

 is capable of producing, but the dose administered is known to be minimum for whatever intensity of re- 

 sponse was produced, use Symbol P. This is explained in more detail in the previous section, General Use. 



3. Coding of questionable test results; use of Symbol Q of Field W 



Occasionally, after analyzing his test data, an author will suggest evaluation and at the same 

 time will place a definite qualification of uncertainty on the exactness of this evaluation. Such 

 conservativeness frequently is expressed, for example, when a particular test method, practical for 

 initial screening of compounds, provides a measure of effectiveness too coarse to assure the author 

 that the apparent biological response (or lack of response- -or the expressed measure of a specific 

 positive response) should be relied upon. Such data could be dismissed from coding or, if positive, 

 they could be given a vague coding evaluation such as Symbol with Criterion 01- -meaning only that 

 "response in some positive degree" was produced. If data on the particular compound or particular 

 organism are rare, however, the data are better coded for what they are worth than lost to the file; 

 furthermore, the author's suggested evaluation is better than one devoid of any rating. 



Symbol Q of Field W has been provided merely to express the fact that the author has pointed 

 out that (1) no response was detected, but the particular method of measuring response (or some other 

 factor than dose size and other variables for which the CBCC code line has specific provision) makes 

 this negative evaluation questionable and candidate for further study or (2) a response was detected 

 (coded as positive data in Fields X and Y), but the method of measuring or some other factor makes 

 this positive evaluation questionable; for example, the response observed may not have been due to 

 the compound or may have been only in part due to the treatment, or (3) a positive response was 

 determined which appeared to be quite high (or quite low), but which, due to the method of measure 

 or some other factor, may be less (or more) than this apparent evaluation. Symbol Q is not to be used 

 by the coder to express his own skepticism or questioning of results or of the author's testing method; 

 it is used to express a qualification put on the evaluation by the author himself, when that evaluation 

 suggested by the author is coded literally in Fields X and Y and therefore needs the author's qualification 

 indicated by Symbol Q. 



4. Criterion 01; author's evaluation; coder's evaluation (in absence of author's evaluation ) 



This criterion was established to permit coding those expressions of evaluation consisting of 

 the author's verbal descriptions of response levels, when the author gives no specific measurements 

 which might serve better as coding bases for finer evaluations. (Criterion 02, discussed in Division 5, 



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