FIELDS W, X. and Y 

 Columns 68; 69 and 

 70; and 71 



was established for essentially the same reason, but deals with author's evaluation expressions in the 

 form of scoring systems rather than verbal descriptions. ) With Criterion 01, only five general categories 

 of evaluation have been actually listed and defined for Field Y (plus one for expressing positive action 

 of unspecified degree). 



In defining these evaluations, the terms "insignificant" and "significant" have been avoided 

 largely because their use has been found to lead to confusion. Sometimes the term "insignificant" is 

 used to mean that the response was positively demonstrated (i. e. , the method of measurement was 

 sufficiently critical to warrant interpreting the measured response as a positive response of specific 

 intensity), but the intensity of response was too low to be considered practical or "significant" for the 

 specific USE for which the author tested the compound. On the other hand, "insignificant response" 

 frequently is used to mean that there was an apparent response, but the conditions of the test or the 

 methods of measurement were such that the measure of response was below the "significant" level; 

 i. e. , the measure was considered to be inadequate evidence that the response actually occurred. For 

 consistency, the CBCC has attached the latter definition of "insignificant" to the definition of Symbol 1 

 (i. e. , inadequate evidence that the response actually occurred) and the other definition (positive 

 activity but too low to be practical for a particular use) is attached to the definition of Symbol 3. 



The terms listed for these categories of verbal evaluation are not exhaustive of the terms the 

 coder might find used by authors, but terms other than those of the list can be fitted to a symbol by 

 examining the list for a reasonable equivalent to the author's term. 



An author's verbal categories may be more or less than the six categories now defined in the 

 Code. For example, there may be only four, "inactive", "slight", "moderate", and "high", of which 

 "moderate" must represent all response intensities from "slight" to "high"; in this case, use of 

 Symbol 6 is indicated for all those responses intermediate between "slight" and "high". On the other 

 hand, still finer categories of evaluation may have been invented by the author (improbable because 

 adjectival terms accurately describing response categories finer than "slight", "moderate", and "high" 

 are limited), in which case Symbols 2, 4, 6, and 8 could be brought into use, in addition to Symbols 5 

 and 7, for degrees of intermediate intensity of response. 



In addition to the use of Criterion 01 as described above for an author's verbal evaluation, its 

 use has been extended (for CBCC coders) to include "coder's evaluation". Criterion 01 should not be 

 regarded as a means of permitting the CBCC coder to express his evaluation of the test result instead 

 of an author's verbal evaluation or instead of using available quantitative data for evaluation according 

 to other criteria. The criterion is, however, intended to permit the qualified coder to evaluate results 

 when the data are not appropriate for evaluation by other criteria in the Code and when the author has 

 not made a definite verbal expression of evaluation. 



When the author's verbal evaluation or the coder's judgment are used as entries in Fields X 

 and Y, Field W will be coded according to what is known about the dosage administered and the 

 extensiveness of testing. If no response occurs (Symbol 1 in Field Y), Field W will be coded with 

 Symbol J or K, according to whether the dose coded in Field M or N were known to be the maximum 

 tolerated dose. If the response did occur (symbols other than Symbol 1 in Field Y), Field W will be 

 coded with Symbol L, M, N, 0, or P, according to what is known about the dose and the maximum 

 intensity of response. If only one dose were tested, Field W would ordinarily be coded with Symbol L 

 or M, according to whether it is administered at maximum tolerated dose. If a series of tests have 

 provided significant information about the dose level administered and the intensity of response pro- 

 duced, Field W may be coded with Symbols N, 0, or P, according to the definitions of those symbols. 



5. Criterion 02; Author's Scoring System 



As in the case of Criterion 01, Criterion 02 was established for test results in which the author 

 gives no measurements that might serve as a basis for coding evaluation, but gives only his own 

 estimate of evaluation of the response; Criterion 02, however, is for translating into code symbols 

 arbitrary scoring systems which frequently are used by investigators to scale test responses (in a 

 sense, being the author's own "coding" scheme). The most common scoring system uses simply plus 

 and minus signs, the minus sign representing "no response" or "inactive" and one, two, three, or 

 more plus signs representing increasing degrees of positive response. However, other symbols and 

 devices are used by authors for the same purpose. 



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