FIELDS W, X, and Y 



Columns 68; 69 and 



70; and 71 



The coding of 0. 25, the relative potency of the test compound, would be by Symbol 3 of Field Y, 

 using Criterion 04. In this case, however, the coding in Field Y does not reflect the intensity of 

 response of either the test compound or standard and reference must be made to coding of the test for 

 activity of a standard compound (on another punched card and code sheet) to learn the intensity of its 

 action. It is to avoid this complication, when retrieving and interpreting coded data, that Criteria 03 

 and 04 should be used by the CBCC coder only when the actual measure of response of the test compound 

 is unavailable and only the quotient for comparison or a verbal comparison are given by the author. 



When the author presents evaluations in terms of comparison to another compound tested con- 

 currently and by the identical method, this comparison should always be recorded in the written 

 abstract, but it should not be coded (using Criterion 03 or 04) unless the author does not give the 

 measure of intensity of response (which could be coded by another criterion) and gives only the 

 quotient of comparison with the standard. Exceptions might be made to this, for CBCC coding, for 

 screening-type tests made on a large number of test compounds (using a constant test procedure for 

 a given biological response) with results expressed in terms of comparison to one standard compound, 

 itself thoroughly tested and coded. 



When it is necessary to use Criterion 03 or 04, note that the result of the test which was per- 

 formed to evaluate the standard compound's activity must always be coded, in order that these data 

 may be available for comparison with evaluation of compounds tested by the identical method and 

 conditions. 



The conversion of actual measurement of response or potency into comparative values (when 

 Criterion 03 or 04 is used) makes coding of Field Y unique. The scale of comparative values has been 

 broken into five ranges and assigned symbols 1, 3, 5, 7, and 9. As has been pointed out, however, 

 this coding has no exact meaning without the coding of the standard compound to which comparison is 

 made, except that it is generally assumed that a compound to which comparison is made has caused a 

 positive response to some more or less satisfactory degree and that the test compound is more or less 

 potent than the standard compound as indicated by the coding in Field Y. 



In addition to numerical comparative expressions (i. e. , numerical quotients of comparison 

 between a test compound and a standard compound), an author occasionally expresses a general 

 comparison verbally-- "more than", "less than", or "equal to" the response to, or the potency of, a 

 standard compound. Symbols 4, 5, and 6 have been assigned to those general verbal comparisons for 

 Field Y when Criterion 03 or 04 are used. 



The following are observations on code entries of Field W, when using either Criterion 03 or 04 

 in Field X. When Criterion 03 or 04 is used, it may ordinarily be assumed that the standard compound 

 has been tested so thoroughly that dose sizes and response intensities to which the test compound is 

 compared are minimum doses causing the intensity of response caused by the standard. When the test 

 compound is known to have produced the maximum response intensity of which the compound is capable, 

 the coding of Field W depends on the dose-response relationship; if the author indicates that the dose 

 of test compound used in his calculations has been demonstrated to be the minimum dose needed to 

 produce maximum response, code Field W with Symbol 0; if the dose of test compound producing 

 maximum response is not demonstrated to be the minimum dose needed to produce that maximum re- 

 sponse, code Field W with Symbol M or N. Field W would be coded with Symbol L or P if the test 

 compound were stated to have produced an intensity of response which is not known to be the maximum 

 intensity of which the compound is capable. (Refer to the section on General Use which distinguishes 

 in more detail the meanings of Symbols L, M, N, 0, and P. ) 



10. Criteria 10, 11, 12, and 13; rating of the compound's ability to produce the response, based 

 on time values 



Criteria 10, 11, 12, and 13 are examples of criteria for which there are scales for units of 

 measure of the response; in this case, the scales are in terms of units of time and they (or Criteria 54, 

 57, 58, and 59, to be described in their turn) are used whenever the test results have been measured 

 in such units. However, because the scale for any one of these criteria is not a fixed scale, but a 

 scale that expands or contracts in scope, to accommodate to the type of specific response produced, 

 the rating of positive response which these criteria afford in Field Y is of little more significance than 

 rating of positive response in Field Y by Criteria 01, 02, 03, and 04, as the remaining paragraphs of 

 this division will explain. 



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