CHEMICAL EQUILIBRIA 



127 



The Danysz Effect for Tetanolysin 

 (Madsen and Walbum) 



A is the solution of antitoxin used ; L the solution of tetanolysin ; 

 1 cc. L was by means of special experiments on neutralization found 

 equivalent to o- 1 8 cc. of A. The calculated effect is taken pro- 

 portional to the free quantity of A. 



Experiments have been carried out by von 

 Dungern on the Danysz effect for diphtheria toxin. 

 He has, however, not let the toxin and antitoxin 

 react upon each other for sufficient time to reach the 

 end effect. His figures are therefore only about 

 half as great as they would have been if he had used 

 sufficient time of action. 



In order to explain the Danysz effect the Ehrlich 

 school supposes the presence in the toxins of a new 

 kind of substances called epitoxonoids, which are 

 neutralized after the "toxons." Of course the sup- 

 position of one new substance corresponds to the 

 introduction of two new hypotheses, the one re- 

 garding its toxicity, the other regarding its quantity. 

 Sachs believed he had found at least two " epi- 

 toxonoids." 



In his epoch-making Dialogue regarding the 



