142 



IMMUNIZATION 



hours do the two different methods show the same 

 effect, and after that time the effect of the sub- 

 cutaneous injection seems to be a little (about 10 per 

 cent) higher. 



Now it is of extreme importance in the case of an 

 attack of diphtheria that the remedy should act as 

 rapidly as possible. Therefore the intramuscular in- 



e3 

 x 



o 



c 

 ra 



o 4- 



c 

 to 



3> 



25 



50 



125 



150 



75 100 

 Time in hours — »> 

 Intramuscular injection Subcutaneous injection 



Fig. 33. 



jection should be recommended for therapeutic cases 

 and not the subcutaneous one, which has hitherto 

 been used in most cases. Against the most rapidly 

 acting intravenous injection some objections of 

 practical signification may be raised. 



After a maximum content of antitoxin has been 

 reached about 75 hours after the injection a regular 

 slow decrease takes place. This decrease has been 



