144 



IMMUNIZATION 



According to this evidently log n = a — bt } where t is 

 the time (in days). In other words the decay of the 

 antitoxin goes on at the same rate as a monomolecular 

 reaction. Bomstein also maintained that the quantity 

 of antitoxin decreased to the same fraction in four 

 days independently of its absolute quantity. The 

 decrease goes on so that in 3-25 days for the dogs, 

 of which three specimens were examined, and in 

 3 days for the guinea-pig, the quantity of antitoxin 

 sank to the half quantity. After the observed value 

 a calculated value is written which, as is easily seen, 

 agrees very well — and within the errors of observa- 

 tion — with the observed one. The magnitude of the 

 errors of observation maybe estimated from the differ- 

 ences between the observed values for the three dogs. 



Passive Immunization with Antidiphtheric Serum 



(Bomstein) 



The table is of great interest because it indicates 

 by a comparison of the observed values for the three 

 dogs with the calculated ones the great improve- 

 ment effected by forming the mean values of two or 



