THE SYNTHESIS OF PROTEINS 



41 



tion that antibody formation is sometimes accompanied by an increase 

 in normal serum globulins. 



Rate of Appearance of Antibodies in the Circulation 



Injection of antigen gives rise after a few days to a rapid increase 

 of antibody in the circulation. In some cases a second injection of anti- 

 gen gives rise to a second and larger increase in antibody, especially 

 if a small amount of antigen were injected the first time. The curves 

 are logarithmic in form and Burnet considers this to be evidence for 

 the existence of some process of biological multiplication. Actually the 



E 



o 



jO 



<0 



o 



4- 



3- 



00 1 



5000- 



Days after injection 



1st injection 



2nd injection 



012345678 



Days 



Figure 3. Production of antibody after varying lengths of time. 



