UNIDENTIFIED VITAMINS 



71 



TABLE V 



Isolation of a Peptide of p-Aniinobenzoic Acid from Yeast 

 (Ratner, Blanchard and Green [ 1946 J ) 



H.,N ^ >CO-polypeptide 



OH N 



N N 



lo-ii /-glutamic acid residues 

 I unknown amino acid 



-CH..NH /' 



^ CO — glutamic acid 

 — tripeptide 



— heptapeptide . 



— dipeptide 

 — tetrapeptide 

 - — pentapeptide 

 — etc. 



. known 



TABLE VI 



Factors Possibly Related Chemically to Pteroylglutamic Acid 



Norite eluate factor 



Folic acid 



Streptococcus lactis R factor 



Vitamins B^q and B^ 

 Factor R 

 Vitamin M 



Spies and his associates reported on nine cases of macrocytic anemia 

 in relapse which showed a positive reticulocyte response and an increase 

 in the red blood cell count after treatment with pteroylglutamic acid. 



Darby and Jones reported satisfactory remissions when two patients 

 with sprue were similarly treated, and Spies reported satisfactory re- 

 missions of tropical sprue. 



Satisfactory remissions for several cases of Addisonian pernicious 



