78 



KARL FOLKERS 



TABLE VII 

 Other Factors Related (?) to Pteroylglutamic Acid 



Growth factors for 

 L. helveticus 

 S. lactis 



Unidentified factor (s) 

 in Hver efifective in 

 blood dyscrasias in 

 rats 



Chloroform soluble 

 fractions from liver 

 folic acid concentra- 

 tion process 



Rats on pantothen- 

 ic acid deficient diet 

 plus L. casei factor 



Barton-Wright. 



Emery and Robinson, 



(1945) 



Daft and Sebrell 

 (1945) 



anemia and pernicious anemia of pregnancy have been reported by 

 Moore and associates and by Amill and Wright. 



Other such clinical observations have now been reported. However, 

 as Moore and his associates pointed out, there is no clinical information 

 as yet as to the effect of pteroylglutamic acid on the neurological mani- 

 festations of pernicious anemia (Table VIII). 



The use of liver therapy for the treatment of pernicious anemia was 

 introduced by Minot and Murphy in 1926. 



Since pteroylglutamic acid has been isolated from liver, it is desirable 



TABLE VIII 

 Pteroylglutamic Acid as an Antipernicious Anemia Substance 



Macrocytic anemia in 

 relapse (9 patients) 



Sprue (2 patients) 



Tropical Sprue 



Addisonian pernicious 

 anemia (2 patients) 



Pernicious anemia of 

 pregnancy ( i pa- 

 tient) 



Addisonian pernicious 

 anemia (6 patients) 



Positive reticulocyte 

 response increased red 

 blood cell count 



satisfactory remissions 



satisfactory remissions 

 satisfactory remissions 



satisfactory remissions 



Spies and associates 

 (1945) 



Darby and Jones 

 (1946) 



Spies (1945) 



Moore and associates 



(1945) 

 Moore and associates 



(1945) 



satisfactory remissions Amill and Wright 



(1946) 



