CELLULAR METABOLISM I3I 



Barron et al. (12) have shown that rf-amino acid oxidase, a sulfhydryl 

 enzyme, was not inhibited by lewisite. 



The close interrelation between the metabolism of carbohydrates, fats, 

 and proteins has shown that for the synthesis of protoplasm energy is 

 obtained by the aerobic oxidation of carbohydrate. The preponderant 



TABLE XI 



The Effect of Very Low Doses of X-Ray on Myosin (Aged). 



part of synthesis reactions over breakdown reactions in growing cells 

 must be due not only to the increased formation of enzymes but also 

 to the distribution of the regulating mechanisms which not only modify 

 the rate of reactions but are also able to change the direction of these 

 reactions. The study of these regulating mechanisms which channel the 

 multiple enzymatic reactions towards different pathways will clarify the 

 role of enzymes in growth processes and will help us in understanding 

 the change from normal controlled growth to the uncontrolled growth 

 of cancer. 



REFERENCES 



1. Auerbach, C, J. M. Robson, and J. G. Carr. Science, lofi, 247, 1947. 



2. Ball, E. G. Ann. New York Acad. Sci, 45, 363, 1944. 



3. Barron, E. S. G. Biol. Bull., 62, 42, 1932. 



4. Barron, E. S. G. /. Biol. Chem., 97, 287, 1932. 



5. Barron, E. S. G. /. Biol. Chem., 121, 285, 1937. 



6. Barron, E. S. G. Adv. Enzymology, j, 149, 1943. 



7. Barron, E. S. G., Z. B. Miller and G. R. Bardett. /. Biol. Chem., 171, 



791. 1947- 



8. Barron, E. S. G., S. R. Dickman, and T. P. Singer. Feder. Proc. Soc. 



Biol. Chem., 6, i, 1947. 



9. Barron, E. S. G., and J. M. Goldinger. Proc. Soc. Exp. Biol, and Med., 



48, 570, 1 941. 



