3M 



THE ACTIVE PRINCIPLE OF ERYTHROPHLOEUM LABOUCHERII, 



increased by 72 millimetres in 20 seconds and the rate of tlie heart beats in- 

 creased by 15 per minute. The blood-pressure then fell and rose again, all 

 iwithin the first minute. After Imin. 40secs. the minimum point was reached 

 where the blood-pressure dropped 52 millimetres below the maximum. It then 

 lose, and remained high during 6 minutes, after which it Ix'gan to fall, and 

 continued till the end of the experiment. 



The resj)irations decreased gradually from lieginning to end. They had 

 lalleu to half the number in 6 minutes, and stopped at 12 minutes. 



From the period of maximum blood-pressure, after 20 seconds the curve 

 of respiration showed an ever increasing period of rest, or broadening out at 

 the end of each inspiration. 



In this experiment the intravenous injection of 0.0025 gram of alkaloid 

 into a dog weighing 3800 grams proved fatal in 12 minutes. This amount is 

 cfiuivalciit to O.fi milligrams jier kilogram of body-weight. 



.Vlter the intravenous injection of 1 mgm. of alkaloid an instantaneous rise 

 was observed in the arterial blood-pressure, which reached its maximum after 

 1 min. and then iell. .Vlter a second injection of the same amount the pres- 

 sure rose again to the same level and tliis time remained up. After 10 minute-s 

 a third injection of 3 milligrams was made. This time, although the mean 

 pressure was unchanged, the maximutii heigiit rose 24 millimctpes. One minute 

 after the la.st injection the pressure began to tall and 2 minutes later the animal 

 was dead. The res])irations after the first small dose were increa.scd in number, 

 but aCter each subseciuent injection no increase was observed. Tlic depth of 

 respirations in this experiment did not alter to any extent. 



A post mortem examination showed tlie heart in diastole, but congested 

 with blood on the right side only. The right ventricle was extremely ililated 

 while the left w.n.s empty. 



The liver, spleen, and intestines were very pale in colour, and iK^istaltic 

 movements were very conspicuous. 



