Discussion Questions — Part E 477 



DISCUSSION QUESTIONS— PART E 



1. Discuss the heat changes observed in intact muscles from the point of 

 view of thermodynamics. 



2. Describe the energy changes occurring during the flight of insects. 

 What is the effect of temperature on the rate of wing beat? 



3. How is a body temperature regulated in humans? Include in your 

 answer a discussion of the metabolic rate, the temperature receptors, the 

 portions of the central nervous system active in temperature regulation, and 

 the role of the endocrine system. 



4. How does the equilibrium constant K vary with temperature for the 

 reaction 



Mb + 2 ^ Mb0 2 



where Mb is myoglobin ? Use this to find the Gibbs' free-energy difference 

 between the two sides of the equation each referred to an appropriate standard 

 state. 



5. Compute the difference in Gibbs' free energy for C0 2 + H 2 and 

 H 2 C0 3 . In terms of this result, discuss the variations of this equilibrium 

 with the temperature. 



6. Outline the rigorous development of absolute rate theory based on the 

 quantum mechanical approach of Kimball and Eyring. 



7. The enzyme systems called luciferase are responsible for the biolumin- 

 escence of fireflies and various other organisms. These systems have been 

 studied in detail as a function of temperature and pressure. Describe the 

 results of such studies in the terminology of absolute rate theory. 



8. Carry through in detail the average-value approach discussed in Chapter 

 23, pages 426-427, including an algebraic evaluation of the parameter 

 A in Equation 12, Chapter 23. 



9. Discuss the hole theory of liquids, comparing it with other models of 

 liquids. 



10. Diffusion theory has been applied to fumerase to show that it is a 

 diffusion-limited reaction. Discuss this proof. 



11. Develop rigorously Equations 17 and 18 of Chapter 23. 



12. Review the evidence for the concept that the secretion of HC1 by the 

 gastric mucosa is an example of active transport. 



13. Describe in detail the experiments which indicate that active transport 

 occurs across the mucosa of the small intestine, resulting in the selective 

 absorption of certain metabolites and ions. 



14. Which molecules and ions have been demonstrated to be actively 



