Section 11 — Immunogenetics 



and, in turn, leads to the tentative conclusion 

 that the inhibitor, at least in some way, resembles 

 the antigen. 



Recent experiments have shown that mixtures 

 of some RNA derivatives and amino acids have 

 a greater inhibitory effect on the Rh antibodies 

 than equivalent amounts of either substance 

 alone. Adenosine monophosphate, uridine mo- 

 nophosphate, and cytidine monophosphate 

 were the nucleotides used in this investigation. 

 The amino acids used were histidine, arginine, 



lysine, phenylalanine, and serine. A number of 

 quantitative relationships between inhibitors 

 and antibodies have been determined. These 

 further support the idea of the complexity of the 

 Rh antigens and therefore the complexity of 

 the genetic material governing Rh. Furthermore, 

 while it is not possible to postulate a definitive 

 chemical composition for the Rh antigens on 

 the basis of these studies, they do offer an im- 

 portant insight into the nature of Rh and into 

 the ultimate unravelling of this problem. 



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