THE PITUITARY GROWTH HORMONE 



367 



FFA (Goodman and Knobil, 1959). Similar observations have been 

 made in man (Raben and Hollenberg, 1959). It should be added that 

 this effect of growth hormone is still demonstrable, in the rat at least, 

 in the absence of the thyroid and adrenal glands (Goodman and 

 Knobil, 1960). 



Since the plasma concentration of FFA is the resultant of both 

 production and utilization, it became necessary to determine whether 

 the effect of growth hormone is explicable in terms of increased mobili- 

 zation of FFA from adipose tissue or decreased utilization of fatty acids 



1.6 



PLASMA 

 NEFA 



H Eq./cc. 



0.8- 



0.6 



0.4 



0.2, -c>: 



SIMIAN GROWTH HORMONE O.lmg./Kg. 



FASTING CONTROL 



PORCINE GROWTH HORMONE 3mg./Kg. 



PORCINE GROWTH HORMONE Img./Kg. 



(P205A) 



BOVINE GROWTH HORMONE 8mg./Kg. 



ALL HORMONES ADMINISTERED IN WATER 

 I.M. AT TIME 



4 8 



TIME IN HOURS 



Figure 6. The species specificity of growth hormone with reference to its 

 action on the concentration of non-esterified fatty acids in the plasma of 

 fasting, hypophysectomized monkeys. (From Goodman and Knobil, 1959.) 



