138 FUNGUS DISEASES OF MAN AND ANIMALS 



Thymol, instilled into the lesion locally and taken by mouth, has 

 been used with success in some cases of actinomycosis and cocci- 

 dioidomycosis. Sulfadiazine is effective in actinomycosis. Penicillin 

 is also reported useful in this disease, but. has not yet been tried in 

 enough cases to permit a critical evaluation. 



No effective specific treatment is yet known for most of the sys- 

 temic mycoses. Rest and supportive therapy are recommended to 

 aid the patient in arresting the infection. Many of the mycoses, 

 even of the more severe types, tend to remain localized, spreading 

 by extension only, for long periods. Where medication proves useless 

 in such cases complete surgical excision or even amputation may be 

 the best treatment. 



LITERATURE 



1. Balls, A. K., The precipitin test in the identification of yeasts, J. Immunol., 



10, 797 (1925). 



2. Blakeslee, a. F., and R. A. Gortner, On the occurrence of a toxin in juice 



expressed from the bread mould Rhizopiis nigricans, Biochevi. Bull., 2, 

 542 (1913). 



3. , Reaction of rabbits to intravenous injections of mould spores, 



Biochem. Bull, 4, 45 (1915). 



4. Bloch, B., Zur Lehre von den Dermatomykosen, Arch. Dermatol. Syphilol. 



{Berlin), 93, 157 (1908). 



5. Bloch, B., B. A. Labouchere, and F. Sch.\af, Versuche einer chemischen 



Charakterisierung und Reindarstellung des Trichophytins. Arch. Der- 

 matol. Syphilol. (Berlin), 148, 413 (1925). 



6. Bloch, B., and R. Massini, Studien liber Immunitat und tjberempfindlich- 



keit bei Hyphomycetenerkrankungen, Ztschr. j. Hyg. u. Infektionskr., 63, 

 68 (1909). 



7. BoDiN, E., and L. Gautier, Note sur une toxine produite par V Aspergillus 



jumigatus, Ann. inst. Pasteur, 20, 209 (1906). 



8. BoDiN, E., and C. Lenormand, Recherches sur les poisons produits par 



Y Aspergillus jumigatus, Ann. inst. Pasteur, 26, 371 (1912). 



9. Browx, G. T., Hypersensitiveness to fungi, J. Allergy, 7, 455 (1936). 



10. Brumpt, E., Precis de parasitologie, Masson et Cie., Paris, 1936. 



11. Cadham, F. T., Asthma due to grain rusts, J. Amer. Med. Assoc, 83, 27 



(1924). 



12. Cbni, C, and C. Besta, Ueber die Toxine von Aspergillus jumigatus und 



A. jiavescens und deren Beziehungen zur Pellagra, Centr. Pathol. Anat., 

 13, 930 (1902). 



13. Conant, N. F., D. S. Martin, D. T. Smith, R. D. Baker, and J. L. Call- 



away, Manual oj Clinical Mycology, Saunders, Philadelphia, 1944. 



14. Cummins, W. T., and J. Sanders, The pathology, bacteriology and serology 



of coccidioidal granuloma, J. Med. Research, -35, 243 (1916). 



15. Davis, D. J., The effect of potassium iodide on experimental sporotrichosis, 



J. Injectious Diseases, 25, 124 (1919). 



