210 INFECTIONS CAUSED BY MOLDS 



this over a pigeon's head for a minute or two, rapidly fatal hemor- 

 rhagic pneumonia develops. Henrici - succeeded in producing only 

 very acute infections in this way. On the other hand, by feeding 

 wheat which had been overgrown wdth the mold, he succeeded in 

 two out of four pigeons in obtaining an infection of the air sacs 

 very similar to the natural disease, death occurring in about 6 weeks. 

 Microscopically both the natural and experimental lesions may 

 vary considerably according to the virulence of the strain. Usually 

 there is extensive necrosis in the vicinity of the organisms, with some 

 suppuration. In the nodular lesions of the lungs there may be some 

 production of fibrous tissue. In the lesions branched segmented 

 hyphal fragments may be found (Fig. 106), with conidiophores in 

 various degrees of development where the fungus reaches a surface 

 exposed to the air. In the miliary abscesses produced by intravenous 

 inoculation one finds small masses composed of radiating filaments 

 somewhat resembling a granule of Actinomyces hovis, save that the 

 filaments are fewer and coarser. 



LITERATURE 



1. Fox, H., Disease in Captive Wild Mammals and Birds, Lippincott, Philadel- 



phia, 1923. 



2. Henrici, A. T., An endotoxin from Aspergillus jumigatus, J. Immunol., 36, 



319 (1939). 



3. Lapham, M. E., Aspergillosis of the lungs and its association with tuber- 



culosis, /. Am. Med. Assoc., 87, 1031 (1926). 



4. Renon, L., Etude sur I'Aspergillose chez les anim,aux et chez I'homme, Masson 



et Cie., Paris, 1897. 



5. Schneider, L. V., Primary aspergillosis of the lungs, Am. Rev. Tuberc, 22, 



267 (1930). 



6. SiEBENMANN, F., Die Fadenpihe rmd ihre Beziehungen zur otomycosis asper- 



gillina, Bergmann, Wiesbaden, 1883. 



t 



MYCETOMA 



Carter - * proposed the term mycetoma to designate a type of 

 fungus infection usually localized to the foot and characterized by 

 a conspicuous deformity in which the foot is greatly enlarged. It 

 was frequently seen in India and, according to Carter, Colebrook 

 introduced into medical literature the name Madura foot by which 

 the condition was popularly known near Madura, India. Carter 

 showed that the condition was not an etiological entity and he de- 



* Literature citations for this section will be found on page 214. 



