THE ALCOHOLIC FERMENTATION PROPER 327 



Mg**, hexokinase 



Glucose + ATP ^ glucose-6-phosphate + ADP (la) 



Mg ■'■■'■, hexokinase, 



Glucose + ADP ^ glucose-6-phosphate + AMP (16) 



myokinase 

 Phosphohexoisomerase 



Glucose-6-phosphate ^ fructose-6-phosphate (2) 



Mg**, hexokinase 



Fructose-6-phosphate + ATP ,^ 



fructose-l,6-diphosphate + ADP (3) 



This hexose diphosphate is acted upon by the enzyme zymohexase 

 (aldolase) to form as cleavage products two triose phosphates — a 

 molecule of glyceraldehyde phosphate and a molecule of dihydroxy- 

 acetone phosphate — an equilibrium existing between the two. 



CH2O-PO3H2 CH2O-PO3H2 



HOC 



HOCH Zymohexase 



HCOH ^ ^ 



HC — 



CH2O-PO3H2 



:c=o 

 CH20H 



Dihydroxyacetone phosphate , . ^ 

 + (4) 



CHO 

 tHCOH 



Fructose -1,6 -diphosphate CH2O— PO3H2 



3 - Phosphoglyceraldehyde 



CH2O— PO3H2 CHO 



Isomerase 



C=0 , HCOH (5) 



CH2OH CH2O— PO3H2 



Dihydroxyacetone 3-Phospho- 



phosphate glyceraldehyde 



The glyceraldehyde phosphate, according to Warburg and Chris- 

 tian,*^ unites with inorganic phosphate to form 1,3-diphosphoglycer- 

 aldehyde. 



OH 



(6) 



