332 



BIOLOGICAL ACTIVITIES OF YEASTS 



H 

 C 



H 



HC 

 HC 



\. 



'CCONH2 



CH 



N= 



f 



N 



^C— N 



NHo 



— N 

 HC- 



-/ 



CH 



N 



HCOH 

 HCOH 

 HC 



HG 



O 



HCOH 

 HCOH 

 HG 



O 



OH 

 + HCO— PO3H2 

 HCOH ;=^ 



CH2O— PO3H2 



1 ,3-Diphospho- 

 glyceraldehyde 



CH2 



o 



0:P — 



-O- 



-O 



GH2 

 o 



-POH 

 O 



Diphosphopyridine nucleotide, 

 Coenzyme I 



H 

 C 



HC 

 HC 



%, 



CCONH2 

 CH2 



N 

 HC- 



HCOH 

 HCOH 

 HC 



N= 

 C= 



N 



HG 



H 

 =C- 



-N 



CH 



=C— CNH2 



N 



O 



HCOH 

 HCOH 

 HG 



O 



O 



+ CO—POsHz 

 HCOH 

 CH2O— PO3H2 



1,3-Diphospho- 

 glyceric acid 



CH2 



o 



POH 



O O 



Dihydrodiphosphopyridine n ucleotide, 

 reduced coenzyme I 



CH2 



O 

 HOP— 



-O- 



The coenzyme for carboxylase, cocarboxylase, consists of thi- 

 amin — a pyrimidine nucleus attached through a carbon atom to a 

 thiazole ring — and two phosphoric acids. The structure as proposed 

 by Lohmann and Schuster -^ is as follows. 



