130 STATE BOARD OF AGRICULTURE. 



"Hog Cholera Serum" is a preventive of hog cholera only. It can 

 not be expected to prevent hogs from dying or becoming sick from any 

 other infection than that of hog cholera or from the disorders caused 

 by intestinal or other parasites. "Hog Cholera Serum" can not replace 

 proper care and feeding of swine or save hogs from dietary troubles 

 other than those caused by the virus of hog cholera. 



The following directions and precautions must be carefully observed 

 in order to avoid bad results for which the serum and virus should not 

 be held responsible. 



METHOD OF TREATMENT. 



"Hog Cholera Serum" or "Hy])erimmune Serum" is the blood drawn 

 from cholera-immune hogs that have been hyperimmunized or treated 

 with large quantities of hog cholera virus subcutaneously or intra- 

 A^enously. This blood is deftbrinated or whipped to remove the clot 

 and contains a small amount of carbolic acid as a preservative. It 

 contains no living genns capable of producing an infectious disease 

 in hogs. It should be kept in a cool (30° 40° F.), dark place where 

 it will retain its potency for some time. 



"Hog Cholera Virus" or disease-producing blood is blood drawn from 

 hogs killed at a certain stage of the disease. It is secured only at the 

 laboratorj' under aseptic and antiseptic conditions, deftbrinated and 

 stored in sterile vessels at a low temperature. It rapidly undergoes 

 putrefaction at room temperature and should not be used after it is 

 several days old'. It should be used immediately upon its receipt and 

 any portion not used should be mixed with a disinfecting solution and 

 the vessels containing it washed with a disinfecting solution. 



There are two methods used in treating hogs for the prevention of hog 

 cholera, viz : the "Serum-Simultaneous Method,'' and the "Serum Alone 

 Method." 



"Serum-Simultaneous IMethod:" Each pig is injected according to 

 the methods described below with the proper doses of "Hog Cholera 

 Serum" and "Hog Cholera Virus." The injections are made "simul- 

 taneously" or at the same time before the pig is released. This method 

 is used in herds in which the disease does not exist or where the disease 

 has just started. Pigs treated by this method are immune for six 

 months to one year or perhaps for life. The method is not dangerous 

 as a rule, but it is attended with greater danger than the "Serum- 

 Alone Method." However, the resulting immunity is much longer than 

 in the case of the "Serum-Alone ]\Iethod" and the additional expense 

 is not to be considered. Pigs that show an elevation of temperature 

 or any other symptoms of hog cholera, or pigs that have been exposed 

 to infection longer than one or two days are treated by this method 

 at some risk. 



"Serum-Alone Method:" Each pig is treated with the proi>er dose 

 of serum onlji. This method is to be used in herds where the disease 

 already exists and is to be used on healthy pigs only. The earlier 

 in the outbreak it is used, the greater the number of animals that may 

 be treated with prospects for a successful outcome. Pigs already sick 

 will probably not benefit by its use. Many pigs, apparently Avell, but 

 already infected with the disease germs, can not be saved by the use 



