112 THE ALUMNI JOURNAL 



The following experiments were, therefore, made to settle this 



matter : 



+ 

 Temperature 8° 



(i) 0.250 Gm. of each of the sulphates of quinidine, cinchonine 

 and cinchonidine were dissolved together with 10 Gm. of sodium 

 sulphate in 100 Cc. of water by bringing to laoiling-point. After 

 twenty-four hours there was no deposit of crystals. 



(2) 0.2632 Gm. of anhydrous quinine sulphate was dissolved 

 with 10 Gm. of sodium sulphate in 100 Cc. of water. After twen- 

 ty-four hours the deposited crystals were collected on a filter, 

 washed with 50 Cc. of water saturated with quinine sulphate, 

 dried and weighed. 0.2524 Gm. was obtained from the original 

 0.2632 Gm. of quinine sulphate used; hence a loss of 0.0108 Gm. 



(3) 0.260 Gm. of anhydrous quinine sulphate was dissolved 

 with 0.226 Gm. of sulphate of cinchonidine, 0.196 Gm. of sulphate 

 of quinidine, 0.195 Gm. of sulphate of cinchonine and 10 Gm. of 

 sodium sulphate with 100 Cc. of water. After twenty-four hours 

 the crystals were collected, washed with 50 Cc. of water saturated 

 with quinine sulphate, dried and weighed. 0.3204 Gm. was ob- 

 tained from the original 0.260 Gm. quinine sulphate used; hence 

 0.0604 Gm. too much was found. 



(4) (a) 0.2726 Gm. and (b) 0.2688 Gm. of anhydrous quinine 

 sulphate were dissolved with 0.250 Gm. of each of the sulphates of 

 quinidine, of cinchonine, and of cinchonidine, and 10 Gm. of so- 

 dium sulphate in 100 Cc. of water. After twenty-four hours -both 

 the solutions were filtered and the crystals collected, washed (a) 

 with 100 Cc. and (b) with 50 Cc. of water saturated with quinine 

 sulphate, dried and weighed, (a) gave 0.3204 Gm., (b) 0.3184 Gm. 

 from the original 0.2726 and 0.2688 Gm. of quinine sulphate used ; 

 and excess, therefore, of 0.0478 and 0.0496 respectively. 



(5) The two quantities of quinine sulphate precipitated in (4) 

 (a) and (b) were dissolved each with 10 Gm. of sodium sulphate 

 in 100 Cc. of water. After twenty-four hours 0.2585 Gm, (a) was 

 obtained from 0.3204 Gm. and 0.245 Gm. (b) from 0.3184 Gm. ; 

 thus a loss of 0.0619 and 0.0734 Gm., respectively, took place. 



(6) The two quantities of quinine sulphate precipitated in (5) 

 (a) and (b) were treated again as in (5). From (a) (0.2585 Gm.) 



