THE ALUMNI JOURNAL 



16 



chain, in other words, it contains a suberane nucleus. Willstattei 

 advanced the following formula, 



CH. 



CH< 



TROPIN. 

 — CH 



CH. 



I 



N— CH, CHOH 



-CH 



CH. 



■2 v.^^ ^"2 



This formula shows that Tropin if a derivative of 



1) Pyrrolidine, 



2) Piperidine, 



3) Suberane. 



1) Pyrrolidine nucleus. 2) Piperidine nucleus. 



CH: 



CH^ 



■CH 



NCH3 

 / 

 CH 



-CH3 



I 



CHOH 



I 

 -CH. 



CH. 



CH. 



— CH- 



\ 

 CH3N 



/ 



— CH- 



2 -^'-2 



3) Suberane (Cycloheptane) nucleus 



CH2 CH CHs 



-CH2 



\ 



COOH 

 / 

 -CH2 



NCH. 

 I 



-CH- 



CHOH 

 I 

 -CH2 



CH,- 



a) Proof of presence of the Pyrrolidin nucleus. 



Willstatter obtained, by oxidation with strong Chromic acid mixture, 

 N Methyl succinimid, according to the following formulae. 



CH.,- 



CH, 



-CH CH, 



I I 



NCH3 CHOH 



I I 



-CH CHj 



Tropin. 

 CH, 



CH. 



CH„- 



rCH CH^ 



I I 



NCH3 CO 



I I 



-CH CH. 



CH, 



CH, 



-CH CH, 



I I 



NCH 3 COOH 



I 

 -CH COOH 



-CH- 



Tropinon. 

 -CH., CH. 



NCH3 COOH- 



CHg CO 



Ecgonic acid. 



CH. 



Tropinic acid. 



CO 



\ 

 NCH, 



-CO 



N Methyl succinimid. 



