Experiments with Tuberculin. 66 i 



rose to 102.6° as did also the Devon grade on the same occasion. 

 This may be explained partly by the fact that both had been 

 driven a distance of seven miles the day previous causing much 

 excitement, and followed by the excitement induced by coming 

 into a new place and herd, and among new people. 



One other point should be named as affecting the temperatures 

 of all the test animals in the early forenoon and late afternoon. 

 The whole herd was put in the barn for feeding and milking, from 

 five to seven in the morning and from three to six in the after- 

 noon, so that at these hours the place was crowded and the distur- 

 bance greater. Elevations of temperatute of a degree and under 

 occurring at such time, and as repeatedly seen in the tested ani- 

 mals are thus accounted for. Such elevations do not show the 

 persistence and the slow gradations of rise and fall which we 

 usually see in the rise caused by the tuberculin. 



Taken all in all then there is nothing in the records of tem- 

 perature that would indicate, either at the time of the test, or 

 later, that the tuberculin had proved in any way inimical to the 

 general health. Had the health been impaired by the repeated 

 operation of the tuberculin it might have been expected that the 

 constitutional disturbance would have been more distinctly 

 marked in the later tests than in the earlier ones, and as no such 

 tendency is observable it may be safely concluded that so far as 

 illness can be indicated by a variation of temperature, test doses 

 of tuberculin, in the absence of the bacillus, does not seem to pro- 

 duce any such illness in the healthy animal. 



It has been alleged that the repeated use of tuberculin on ani- 

 mals slightly tuberculous, abolishes the tendency to reaction 

 under the use of this agent. If this were true it would argue 

 rather a curative than a malific action of the tuberculin, but in 

 other experiments, I have found the second test made a week or 

 more after the first to produce a no less marked reaction, so that 

 this alleged tolerance need not be taken into account in the cases 

 before us. 



RESPIRATION AND PUESE. 



As regards the record of the pulse and breathing given in the 

 tables it is sufficient to say that they furnish no real indication of 



