Experiments with Tuberculin. 667 



the milk is given in table XII from which it will be seen that the 

 single test of cow No. 113 there was a slight reduction of the 

 total solids, and of the different constituents such as sugar, 

 albuminoids and fat. The second cow, No. 217, tested three 

 times under tuberculin and once on five successive days without 

 tuberculin gives a more trustworthy basis for estimating the effect 

 of that agent. It will be observed that on April ist under the 

 tuberculin there was a slight decrease of the total solids (0.45),' 

 on April 13th under tuberculin a still larger decrease (1.26), but 

 on June 5th under tuberculin there was an increase (i.oi). On 

 June nth to 15th without tuberculin there was a variation in the 

 total solids of 1.99. 



Then as to the milk sugar, 217 showed a percentage reduction 

 of 0.1 April ist under tuberculin and of .61 April 13th, but no 

 change whatever June 5th though again under tuberculin and no 

 change June nth to 15th without tuberculin. 



Of albuminoids 217 showed a percentage reduction of .07 

 April ist under tuberculin, but an increase of .13 April 13th and 

 .61 June 5th. In the absence of tuberculin it showed a variation 

 of .42 June nth to 15th. 



In fat, No. 113 had a decrease in her single test, while 217 had 

 an increase in all cases under tuberculin .31 April ist, .13 April 

 13th, and .86 June 5th. In the entire absence of tuberculin June 

 nth to 15th she showed a variation of .51. 



With such a testimony it would be disingenuous to claim, any 

 constant or appreciable variation as the result of the injection of 

 a test dose of tuberculin, into a healthy animal even if such dose 

 were repeated several times. So far as there is evidence before 

 us, everything points to the harmlessness of a single test dose on 

 a sound animal system. James Law. 



Cornell University, Ithaca, N. Y., 

 January 8th, 1895 



