8o Bulletin 141. 



ileum, were of a dark reddish color. The lungs and 

 heart were not changed. The brain was deeply con- 

 gested. 

 Pig No. 5. This pig showed lesions very similar to those exhibited 

 by No. 4. The essential difference was an increase in 

 the intestinal congestion. 

 Pig No. 7. The skin between the thighs and about the nose was of 

 a bright pinkish color. The liver was small, exceed- 

 ingly firm and friable. The mesenteric blood vessels 

 were injected and the mesenteric glands were enlarged 

 and cedematous, and many of them deeply reddened. 

 A few were hemorrhagic. Spleen normal. The cortex 

 of the kidneys very pale, but the papillae were abnor- 

 mally dark. The mucous membrane of the intestines 

 was congested in a few irregular areas. The mucosa of 

 the stomach covered with a thick layer of mucus. The 

 heart and lungs were normal in appearance. The brain 

 was very much congested. 

 Pig No. 8. The tissue changes in this animal were similar to those 

 found in Pig No. 7, with the exception that the kidneys 

 were much congested. 

 A careful bacteriological examination was made of the liver, 

 spleen, kidneys and blood of each animal that died. In nearly 

 every instance (all but two) the tubes of culture media (agar and 

 bouillon) inoculated remained clear. The two exceptions contained 

 saprophytic bacteria and were probably contaminations from the air. 

 This examination shows that the alkali had not favored the migration 

 of the bacteria from the intestines to the various organs of the body. 



In order to check the results, several pigs from the same litters as 

 those used in the experiment were kept in adjacent pens, and given 

 the same kind of food. They all remained well. This fact, in addi- 

 tion to the negative results from the bacteriological examination, and 

 the peculiar nature of the lesions, are sufficient evidence that the sick- 

 ness and the fatalities among the pigs in the experiment were due to 

 the soap administered. 



It is important to note that the lesions found in the pigs which died 

 in the experiment were similar to those found in the pigs in certain of 

 the outbreaks mentioned among swill-fed hogs. Considering the facts 



