pole of the spindle. Chromosomes still surrounded by a nuclear 

 membrane, to which they are connected by linin fibres. Iron haema- 

 toxylin and Bordeaux red. 



Fig. 46. The central spindle has nearly disappeared ; centrosomes farther apart ; 

 granules in the cytoplasm about the asters arranged into rows pre- 

 paratory to the formation of additional rays. Iron liEematoxylin and 

 Bordeaux red. 



Figs. 47-49. Three successive stages. The asters have moved much farther 

 apart. New cytoplasmic rays forming between asters and nucleus. 

 The deep centrosome has become differentiated into centriole and cen- 

 troplasm. In Figure 47 the sphere-substance around the deep centro- 

 some is composed of a medullary and a cortical layer, and both nuclear 

 membrane and linin fibres are conspicuous ; in the following stages 

 (Figs. 48, 49) both become less so and finally disappear. The chromo- 

 somes in Figures 48, 49, have divided and from them have grown out 

 fine (spindle) fibres. 



