42 



KANSAS UNIVERSITY SCIENCE BULLETIN. 



Curve 11. Toxic effect of KCl m% counteracted by CaCl2 m/32 for the 

 upper curve. For lower curve, the lever was attached to the ventricle, 

 and to the gill arch for upper. 



Curve 11. 



m mmvm]^'''^^^^^^^^^^ 



■^ '^ " f+!2 Ca Cl 



uKU 



K ci " r c« «i ^ 



X K CI m - 



Tlonml 



Showing the antitoxic and stimulating action of CaCl2 2 cc. m/4 KCI4- 

 m/32 CaClo. Rate of heart contractions increased. KCl m/4 decreased 

 the force of heart and respiration, while rate of respiration increased. 

 The difference between the effect of m% KCl and KCl m% plus 

 CaCl2 m/32 demonstrates that CaCl2 increases force of heart and respira- 

 tion. 



Curve 12. Toxic effect of KCl m% or m/1 counteracted by a previous 

 dose of CaCl2 m/4. For lower record the lever was attached to the ven- 

 tricle, and to the gill arch for the upper curve. 



Curve 12. 



^C^Cl 



tnX KCl 



caA/v^ 



5 KCl 



Following 8 cc. of gradually increasing to m/4 doses of CaCl2 the 

 heart became distended and contracted more forcibly, due to the intra- 

 cardiac pressure; m% KCl injected increased the rate of cardiac and 

 respiratory activity and an m/1 KCl injected ten minutes later failed to 

 produce its usual toxic effect. 



Curve 13. KCl m% following m% CaClo. After m% CaCb was in- 

 jected the pressure stood 14 mm., heart rate 24 and respiratory 36. At 

 3:50 P. M. KCl m% was injected. In one minute pressure fell to 2 mm., 

 heart rate to 4 and respiratory rate increased to 42. At the end of two 

 minutes pressure stood 14, heai't force increased rate 8, respiratory I'ate 

 48, force less. At the end of five minutes pressure and heart action were 

 quite normal while respiration was abnormal in rate but normal in force. 



Curv-o 13. 



CaCl "> !!' 



KCI "X 



fXTt\r\ 



r\^^^^/'^^'^A/^^vr\^\^v^^J\A/^AA^\P\/^^ 



Upper curve, heart and pressure from abscissa. Lower curves, res- 

 piration. Time, five seconds. Records with Hiirthle and lever manometer. 



