THE KANSAS UNIVERSITY 

 SCIENCE BULLETIN. 



Vol. V, No. 12] MARCH, 1910. [vo'^xv^noTb 



CELL CHANGES IN THE ALVEOLI OF A CARCINOMA 



OF THE MAMMA. 



BY EARL F. CLARK. 



(Contribution from the Zoological Laboratory, No. 188.) 



Submitted in partial fulfillment of the requirements for the degree of Master of Arts. 



Plates XLVI to XLVIII. 



THE literature upon the pathological new growths of the 

 human body scarcely mentions amitosis as a method of 

 cell increase. It occurred to me to treat in a comparative 

 way the two methods of cell division, mitosis and amitosis, as 

 they are found in neoplastic material. 



It is not intended to make this paper conclusive, but to make 

 it the first of a series of case studies from the results of which 

 a general conclusion may be deduced as to the relative im- 

 portance of indirect and direct cell division in these new 

 growths. 



I am indebted to Dr. M. T. Sudler for the following history : 

 "In the first week of October, 1907, she fell, bumping the 

 breast against a hard object. No further notice was taken of 

 the incident, however, until the latter part of November, when 

 she noticed a hard, thin, round lump in the right breast about 

 the size of a silver dollar. It was then freely movable. About 

 the 25th of December she noticed a tingling in the right arm, 

 and on January 1, 1908, the arm began to ache. The original 

 mass increased rapidly in size until the whole breast was in- 

 volved. Its rate of growth seemed intermittent, some weeks 

 being much more rapid than others. Upon examination the 

 entire breast was found to be occupied by a hard, firm mass, 

 which was intimately incorporated in the connective tissue of 



(209) 



