THE KANSAS UNIVERSITY 

 SCIENCE BULLETIN. 



Vol. VII, No. 12] JANUARY, 1913. [v'orilMrNo' 



THE INFLUENCE OF ADRENALIN, MODIFIED BY SALT 

 SOLUTIONS, ON BLOOD-PRESSURE IN THE FROG. 



BY IVAN ROY BURKET. 

 (Froiti till' laborntuiy of the Phyt^i<.il(»'4> Brparliiiriit. Universily of K.ansas.) 



THE technique for obtaining blood-pressure in the frog is 

 much simpler than that required in the determination of 

 the blood-pressure in mammals. It was, therefore, under- 

 taken to ascertain the relative merits of the two methods in 

 the standardization of adrenalin. In this connection, also, the 

 attempt was made to determine whether or not the action of 

 adrenalin in the body is modified by the presence of various 

 organic and inorganic salts, which may either be present 

 normally in the blood or be otherwise used therapeutically. 



Very little work has been done on the blood-pressure in the 

 frog except to determine the effect of external influences. 

 Schulzi, in his paper on the effect of temperature, vagus stimu- 

 lation, etc., made some assertions which I have been unable 

 to corroborate and which I will discuss later. His method of 

 operating, however, is the one I found to be most convenient 

 and practical and is used throughout my experiments. 



Neither is literature very extensive on the influence of solu- 

 tions of various salts on mammalian blood-pressure. A few 

 experimenters, however, have published articles along this 

 line of research, and these will be referred to in the discus- 

 sions of the several salts. 



I have been able to find only one paper- on the influence 



Received for publication December 8, 1912. 



1. Sehulz; Archir. fiir die Gesammte Pliysiologie, 1906, CXV, 386-447. 



2. Prankl: Archiv fiir die Gesammte Physiologic 1909, CXXX 346-3.53. 



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