HYDE, ETC. : REFLEXES MODIFIED BY ALCOHOL. 237 



and affect the muscle tone, vaso motor and cutaneous thermal 

 reflex actions to a degree depending upon the susceptibility 

 and condition of the nervous centers. 



Doses of 0.1 cc. of 15 per cent alcohol per 10-gram frog would 

 be equivalent to one pint of sherry or orange or port wine, or 

 1.13 pints of claret or two pints of strong beer for a man of 

 average weight. This dose caused in the frog a depression of 

 the reflex time of the cutaneous sensory organs. 



Explanation of Table I. 



A copy of a table of observations chosen at random, 0.8 per cent acetic 

 acid used as a stimulus. 



Column 1 records at intervals the time of day, in hours and minutes, 

 when the experiment was conducted, first on the unalcoholized and later 

 on the alcoholized frog. 



Column 2 records the reading of the second hand of the watch when the 

 acid paper was applied. 



Column 3 records the reading of the second hand when the frog at- 

 tempted to rub off the paper. 



Column 4 gives the reflex time; that is, the seconds elapsing between 

 the application of the acid and the attempt of the frog to rub it off. 



Column 5 indicates the area on which the acid paper was put. See 

 figure 1. ( — ) means that the frog failed to react within one minute. 



From such data we would conclude : 



1. That this particular frog had been at the beginning of the experi- 

 ment quite normal, in that it responded well to the stimulation and quite 

 constantly, the reaction time being about the same for the same spots, 

 even at quite different times of the day (10 A. M. and 4:30 P. M.). 



2. That the reflex centers of most of the spots had been immediately 

 affected by injecting 30 per cent alcohol in the amount of 0.1 cc. per 10 

 grams of its weight, c being the only spot not quickly affected. 



3. That spots a and 6 were most quickly and longest affected, not 

 reacting once within about an hour and a half after the injection, at 

 which time the experimenting was stopped for that day. That c was 

 least affected, being one of the spots which never failed utterly to react. 



4. That the frog was not quite normal the following day, reacting 

 somewhat more irregularly than normally. 



5. That this dose is not sufficient to produce any apparent effect on the 

 turn-over, swimming, compensatory and equilibrium reflexes. 



