92 



attack, and then waits for another. The system, he says, becomes 

 accustomed to it ; and its curative effect is lessened if used in the 

 intervals, and it loses its anti-periodic influence. Prof. Dickson* 

 says, "A medical friend in Alabama assures us he has given thirty 

 grains every hour for seventeen hours in succession." Again, "We 

 have heard authentically of a western physician who gave an ounce 

 in one night" to a patient with bilious fever. Again, "From thirty 

 to fifty grains are spoken of as a familiar dose; and even one hun- 

 dred grain* are occasionally given at one dose with safety and strik- 

 ing success." 



Martin Solonf says, "Magendie asserts that two grains of sul- 

 phate of quinine are sufficient to arrest the course of intermittent 

 fever;" but most physicians prescribe it in larger doses. Thus, an 

 adult may take during an intermission six grains for a quotidian, 

 eight for a tertian, and twelve or more for a quartan. According 

 to Guersant and Reveillon, a Dr. Bazire gave his wife, ill with ma- 

 larial fever, "in a very short space of time two hundred and forty 

 grains." Soon after, the symptoms increasing, "he gave her, at one 

 dose, three hundred and seventy-five grains." Being now taken ill 

 himself, he took, by the mouth and rectum, nine hundred grains in 

 a very short space of time; and, in the period of eight or nine days, 

 he took five ounces. He died, and she recovered imperfectly, re- 

 maining deaf and blind for some time, and then only partially reco- 

 vering. 



Dr. Dowling,! of New Albany, Indiana, in an article " On 

 Endemic Summer Diseases," says of the treatment of remittent fever, 

 " Occasionally during a remission I have ventured on quinine, and, 

 although by no means certain that it has not proved beneficial, yet 

 it is not my general practice to give it under these circumstances; 

 nor, in truth, do I consider this, or any other preparation of bark, 

 at all essential to the cure of remitting fever. During convalescence 

 it may answer very well, in small doses, as a tonic ; but even here 

 I prefer the chalybeates, elixir of vitriol, or cold infusions of chamo- 

 mile or columbo." Yet he admits its usefulness in intermittent fever, 

 and gives rules for its employment, by following which, "in a vast 

 majority of cases, the cure may be completed by quinine alone." In 

 the treatment of "congestive chills" he says: "I have but little to 

 say. Quinine and calomel are the remedies in which I place the 



* South. Jour, of Med. and Tharm., 1846. 



■j- Diet, de Medecine et de Chirurgie, — Art. Quinquina. 



j West. Joum. of Med. and Surg., July 1847. 



