EPITOME OF EVIDENCE ON PLEURO-PNEUMONIA. 247 



very large one. I think that there would be about eighty cows. 

 After an examination, carefully conducted, I found seven cases, 

 and had them all destroyed ; some of those cases were only 

 strongly suspicious. When they were destroyed, all of them 

 were found to be affected more or less with disease. We inocu- 

 lated all the other animals, with the exception of two or three 

 that were very close on their calving. We did not lose an animal 

 after that, and there was no more disease. In dealing with 

 inoculation it does not follow that with the most careful examina- 

 tion you may be able to hit on all the cases on your first visit. 

 If there are any other cases developing the disease, and they 

 are inoculated, those animals will declare themselves within 

 fourteen to twenty-one days, and show the disease so distinctly 

 that there need be no doubt about it. So firmly is that my 

 opinion that, in dealing with an outbreak, after I get over the 

 fourteenth day I am satisfied there will be no more slaughter- 

 ing. I have had a rare case occurring in the third week. 

 There are many methods of performing the operation, and if the 

 virus is properly introduced it produces a lesion. Unless this is 

 carefully and properly made, you do not get inoculation. When 

 I get inoculation at the seat of operation it is always the same 

 lesion. I can distinguish certain phenomenal appearances at the 

 seat of inoculation that satisfies me whether it has been effectual 

 or not. It may vary in intensity, but it is the same lesion. 

 In the case of a cow falling down against the manger, or getting 

 a kick on any part of the body, you get a specific exudate at the 

 seat of the blow, evidently the pleuro-pneumonia exudate. 

 When I have inoculated a lot of animals with the same virus 

 exactly in the same way, and at the same time, and get from a 

 few or even from one of these animals a specific lesion, and 

 though I do not get it strongly developed in the others, if they 

 get over the fourteenth day, they are safe. I have perfect confi- 

 dence in the quality of the virus, if I know that I have got a 

 lesion produced in a few. If an animal has pleuro-pneumonia, 

 you get one of two results. You get an aggravated lesion, or 

 none at all. I do not think that it aggravates any disease that 

 might be in the lung itself. You have an alteration of the lung 

 lesion from a contagious to a non-contagious one where you have 

 disease in a limited area. You would be surprised how bad 

 an animal may be, and yet escape observation. I have myself 

 made individual examination of animals, and I have passed 

 animals apparently healthy, showing no indication of pleuro- 

 pneumonia, aud yet in a week they have shown that they ought 

 to be destroyed, and have been ill for three weeks. You may 

 have a large lung lesion without being able to detect it. I do 

 not think inoculation aggravates the lesion. But this I can 

 say, that it aggravates the general condition that develops 



