388 MEDICAL MYCOLOGY 



in support of internal origin comes from the symmetrical distribu- 

 tion of rashes or eruptions (the u id" lesions) on the body surface 

 and from the isolation of spores from the circulating blood. Greg- 

 ory (1935) summarized the findings of various workers regarding 

 the isolation of fungi from the blood. He noted that among the 

 fungi isolated are Trichophyton inter digit ale, T. granulosum, T. 

 gypseinn, T. cerebrifonne, A chorion schoerleini, A. qiiinckeanuni, 

 and Microsporia!! audouini. 



Wise and Wolf (1936) pointed out that the vesicular eruptions 

 on the hands of patients with primary mycotic infections on the 

 feet may not necessarily be ids. In their opinion, however, such 

 eruptions, except in persons with occupational eczema or eczema 

 of unknown cause nearly always occur coincidentally with in- 

 fection of the feet. 



Species other than Trichophytoneae may evoke the formation 

 of ids, as Monilia | Hopkins ( 1932) ] and Sporotrichum are known 

 to do. Evidence presented by Hopkins shows that Monilia in the 

 alimentary tract may produce substances which induce skin lesions 

 in the sensitized person. 



Some persons possess a related allergy to such common fungi 

 as Cladosporium, Penicillium, and Aspergillus, present in house- 

 hold dust or in clothing. Consideration of this subject is outside 

 the province of this book; the student may introduce himself to 

 this problem by consulting the report by Rackemann, Randolph, 

 and Guba (1937-38). They found that the tomato-mold fundus, 

 Cladosporhnn fulvum, may irritate the nasal mucosa and eyes, 

 producing asthma. 



Ids may also appear on sensitized animals. De Lamater and Ben- 

 ham (1938) inoculated Trichophyton gypseinn through the skin 

 and into the blood stream of guinea pigs, whereupon widely dis- 

 seminated fungus-free lesions developed. 



Fluorescence. Margarot and Devese (1924-25) made the in- 

 teresting observation that the affected hairs of patients with Alicro- 

 sporum ringworm or with favus and also cultures of the causal 

 fungi exhibit a greenish fluorescence if examined with ultraviolet 

 light filtered through Wood's nickel oxide glass. This discovery 

 has proved a useful tool in diagnosis. Others have confirmed and 

 extended these observations and have sought an explanation of the 

 source of these fluorescent properties. Kinnear ( 1931 ) concluded 

 that fluorescence is resident in the fungus itself in the case of 



