244 Ninth Annual Report of the 



Respecting the swelling at the seat of inoculation, Mr. Fadyean 

 says as follows: 



" Iii interpreting the local reaction to mallein attention 

 must be paid to two points, viz.: the extent of the swelling and 

 the period at which it reaches its maximum size. The rule that 

 regards the first of these is that in the non-glandered horse the 

 swelling that forms at the seat of infection is seldom or never 

 more than three inches in diameter, while in a glandered horse 

 it is seldom or never less than five inches in diameter, and not 

 rarely it is nearly twice that. The rule regarding the second 

 point is that in a non-glandered horse the local swelling attains 

 its maximum size during the first fourteen or sixteen hours after 

 the injection and then readily declines, so that it has nearly 

 or altogether disappeared by the twenty-fourth hour. In a 

 horse suffering from glanders the tumor continues to increase in 

 size to about the thirtieth hour after inoculation; it persists for 

 two or three days, then gradually recedes, and does not finally 

 disappear until the fifth or sixth day." 



Mallein is very useful as a diagnostic agent; while it is not an 

 infallible test, yet it has given very satisfactory results to the 

 Department. A number of its charged failures are probably due 

 to some misunderstanding in the use of it. 



The following shows the form of temperature record for mal- 

 lein tests used by me: 



