48 THE BUREAU OF SCIENCE 



remarkable enlargement of the spleen of infected guinea pigs 

 have been carried on. 



Leprosy. — A study is being made of the organisms cultivable 

 from leprous tissues, with especial reference to classifying the 

 organisms cultivated from such sources by different authors and 

 to determining the etiologic relationship of such organisms to 

 leprosy. 



E7itamoehic dysentery. — The investigation of entamoebic dys- 

 entery, which has extended over a period of nearly three 

 years, has been completed and will be published in six parts, 

 occupying the whole of No. 4, Section B, The Philippine Journal 

 of Science, of the current year under the title Experimental 

 entamoebic dysentery. 



Part I. Introduction. 



Part II. Feeding experiments v/ith cultures of amoebae. 



Part III. Feeding experiments with Entamceha coli. 



Part IV. Feeding experiments with "Entamoeba tetragena" and Entamceha 



histolytica. 

 Part V. Applications of the results to the diagnosis, treatment, and pro- 

 phylaxis of entamoebic dysentery. 

 Part VI. Summary and conclusion. 



Balantidiasis. — As indicated on page 20 little is known about 

 the epidemiology of balantidiasis. The infection presents the 

 following problems which are under investigation : 



1. The frequency of human infections with Balantidium coli in the Phil- 



ippine Islands. 



2. The presence of the parasite in the domesticated pig in the Philippines. 



3. The question of the identity of the balantidium of the pig and of man. 



4. The part played by the pig in the dissemination of the infection to man. 



5. The experimental infection of animals. 



6. The ability of Balantidium coli to penetrate the sound intestinal epi- 



thelium. 



7. The pathogenesis of Balantidium coli. 



8. The cause and nature of the latent infections with this parasite. 



9. The early, preulcerative, pathology of balantidiasis. 



10. The treatment of balantidiasis. 



The results of a portion of this work have been published in 

 The Philippine Journal of Science. Investigations are now in 

 progress which promise to throw much light upon the other 

 problems presented by this parasitic disease. 



Malaria. — In January of the present year a joint commission 

 of representatives from the Bureau of Science, the Bureau of 

 Health, and the College of Medicine and Surgery of the Uni- 

 versity of the Philippines made a sanitary survey of the San 

 Jose estate and adjacent properties in Mindoro, with special 



