contains 13 brief to medium-length reviews or research reports by North- 

 American authors. Three are of broader biological significance: H-Y Antigen 

 and abnormal sex differentiation (Wachtel and Koo) , True hermaphroditism: 

 etiology and phenotypic considerations (Simpson) , and Abnormalities of the 

 Mullerian and Wolffian duct systems (Sarto and Simpson) . 



DEVELOPMENTAL PATHOLOGY, CANCER (see also 78,83,96) 



Monographs 



51. 



T.V.N. PERSAUD. 1979. PRENATAL PATHOLOGY; Fetal medicine 



Thomas, Springfield. XII, 199 pp., 76 figs., 31 tabs., subject index, $ 23.00 



Contents: I. Pathophysiology of the early conceptus, II. Embryogenesis and 

 developmental studies, III, Regulatory processes during normal and abnormal 

 development, IV. Intrauterine growth and fetal maturity, V, Environmental 

 causes of developmental defects, VI, Morphology and function of chromosomes 

 (by M.Ray), VII. Antenatal diagnosis of genetic diseases, VIII. Prenatal 

 /detection of external malformations, IX, Common neonatal problems (by H. 

 Rigatto) 



Although this monograph was written primarily for doctors it might be of 

 interest to teratologists. The book intends to bridge the gaps between the 

 many medical disciplines concerned with the fetus. It is a concise survey of 

 the most recent and significant research developments. The treatment is high- 

 ly selective but much useful information is brought together in numerous 

 tables. 



The book is well produced and illustrated and has a selective bibliography 

 of some 450 titles that runs into 1977. 



52. 



G.B.PIERCE, R.SHIKES and L.M,FINK. 1978. CANCER: A problem of Developmental 



Biology 



Prentice-Hall, Englewood Cliffs, NJ. Found, of Devi. Biol. Series. 



XIII, 242 pp., 28 figs., 4 tabs., subject index. $ 20.75, E 11.65 



Contents: 1. introduction, 2. The early development of neoplasms, 3. Tumors 

 as caricatures of tissue renewal, 4. Structure and biochemistry of neo- 

 plasms, 5. Origin of neoplastic stem cells, 6. Carcinogenesis, 7. Genetics 

 and neoplasia, 8. Controls, 9. Immunity and neoplasms, 10. Metastasis, 11. 

 Cancer therapy 



Obviously this monograph was written primarily for graduate medical stu- 

 dents, but the authors' developmental approach makes it suitable as back- 

 ground reading for those biologists who decide to "utilise cancers as easily 

 manipulated models of normal tissue" (quoted from the Preface) . The treat- 

 ment is highly selective and only literature is cited that contributes di- 

 rectly to the theme of development and neoplasia, 



Ch.3 is of most practical significance to developmental biologists because 

 it contains concise descriptions and discussions of four "prototype" tumours, 

 all containing multiple stem cell lines, each with different properties: mam- 

 malian teratocarcinomas, squamous cell carcinoma, neuroblastoma, and leukemia. 

 Their common denominator is that malignant stem cells may produce normal pro- 

 geny. Also useful is the appendix at the end of the book, supplying clinical 

 and other data on eight commonly studied tumours in man and mammals. 



The book is illustrated mostly with light and electron micrographs. The 

 bibliography contains some 500 titles which run until 1976. 



222 



