REF. | 190 
REFRIGERANTS. 
These are remedies which have been supposed Re 
to diminish the heat of the body without occasion- — 
ing diminution of sensibility or nervous energy. 
it has been assumed that they do this whether in- 
ternally taken or externally applied, by acting — 
with an immediate reducing force on the sanguif- 
erous system. They constitute the second section 
of Cullen’s class of sedantia. After an atten- 
tive review of the grounds on which this class has 
been established and continued—after duly weigh- 
ing the facts and phenomena, chemical and physi- 
ological, which haye been brought in support of it 
—after surveying the wide field of hypothesis and 
conjecture, on which these facts and phenomena | 
have been martialled into an arrayed force to com- 
pel an accrediting consent to the real existence of 
remedies which generate cold in the body—after 
pondering on Dr, Crawford’s doctrine of the chemi- 
cal origin of animal heat: and that more generally 
recived theory supported by Brodie, of the inhe- | 
rent principles of animal heat co-existent with 
and dependant on the living principle which ani- — 
mates the frame; both of which theories are inti- 
mately involved in the course and bearings estab- 
lished for the operation of refrigerants—after 
reflecting on Brockley’s observations, predicated 
on the phenomena of the chemical solution of the 
neutral salts—after attaching as much importance 
to Turberville Needhams theory of an expansive 
