300 ANNUAL REPORT OF THE Off. Doc. 



the spleen was thickly covered with tubercles 1 mm. in diameter. In 

 the substance of the spleen no nodules could be found, but scrapings 

 from cut surfaces showed a large number of tubercle bacilli. The 

 liver showed no microscopic tubercles, but scrapings from cut sur- 

 faces were rich in bacilli, and in sections under the microscope tuber- 

 cles were seen, with a few giant cells. Microscopic examination of 

 the lungs, however, revealed no tubercles. The infection in this ani- 

 mal was dilfuse, and it is considered as a case of tubercular sep- 

 ticemia. 



Both of the goats inoculated with human culture K gained in 

 weight aiid were killed after six months and twenty-one days. Both 

 were in good condition, having a considerable amount of fat in the 

 subcutaneous tissues and around the abdominal organs. In the 

 larger animal at the point of inoculation there was an area of ad- 

 hesion to the pleura about S mm. in diameter. On the surface of the 

 left luog were two or three nodules about 3 mm. in diameter which 

 had undergone caseation. This lung is attached at its lower edge 

 to the diaphragm by fringes of fibrin, and along this edge a few 

 nodules about 12 mm. in diameter and containing chees}' pus were 

 found. The entire surface of the left lung was covered with fringes 

 of fibrin of a reddish-pink color. In both bKigs the elasticity was 

 preserved and neither revealed nodules either by palpation or on 

 section. The left pleura was covered with a network of fibrin similar 

 to that seen in the lung; the right was normal. The mediastinal 

 glands were much enlarged and calcareous. In the liver two small 

 nodules were found near the surface, the organ geing otherwise nor- 

 mal. In the smaller animal the omentum contained upwards of a 

 hundred nodules from 2 to 12 mm. in diameter. The left lung was 

 attached to the pleura at its edge by numerous bands of fibrin and 

 at its posterior surface to the diaphragm in the same manner. 

 Along the lower border were a number of nodules about 6 mm. in 

 diameter which had undergone caseation. The right lung was nor- 

 mal. The mediastinal glands w^ere enlarged and calcareous. The 

 left pleura shows ten or twelve nodules 6 mm. in diameter, which are 

 cheesy; besides a large one, corresponding to the point of inocula- 

 tion. The diaphragm is attached to the spleen and to the stomach 

 by bands of fibrin, but no nodules were found. The liver was nor- 

 mal; the portal glands were enlarged and contained many cheesy 

 nodules. The left kidney contained a number of cheesy nodules. 

 The right kidney was normal. The mesenteric glands were en- 

 larged and several of them contained calcareous areas. 



