314 ANNUAL REPORT OF THE Off. Doc. 



from uiaii was eigbty-eight and one half days; for the three inocu- 

 lated with tissues of other pigs which died, the average was twenty- 

 two days, lii the two first the lungs were invaded throughout with 

 miliary tubercles, and one showed areas of pneumonic character. In 

 neither was the abdominal cavity involved. Of the four pigs inocu- 

 lated with material from the other pigs which had succumbed to 

 inoculation wiih human tissues, three presented a diffuse tubercular 

 pneumonia, rapidly fatal, one living only thirteen days. The remain- 

 ing animal was normal with the exception of the right lung and 

 pleura. Both visceral and parietal pleurae were largely covered 

 with nodules 2 mm. to 12 mm. m diameter, many of them caseous. 

 The lung was dense throughout, and contained many caseous areas, 

 most marked near the surface. 



Sheep. Bovine Material. Two Animals. — Both died, the one in- 

 oculated directly with bovine material in forty-four days, the other 

 in thirty-two days. Both were considerably emaciated, and in both 

 the disease was confined almost entirely to the thoracic cavity, tbe 

 spleen being the only abdominal organ involved, and this only 

 slightly so. In both the lungs showed hepatization, more marked 

 in the one inoculated with the tissues of the guinea-pig. 



Sheep. Human Material. Two Animals. — Both were killed 202 

 days after inoculation. One was entirely normal, with the exception 

 of an area in the right lung 5 cm. in diameter at the point of inocu- 

 lation, in the centre of which was a caseous abscess, the pus con- 

 taining many tubercle bacilli. The second animal was normal 

 throughout. 



Dogs. Bovine Material. Two Animals. — The dog which received 

 the bovine material direct became markedlv ill, much emaciated, 

 and died after 148 days. The pleural surfaces of both lungs were 

 covered with minute nodules, and were almost completely consoli- 

 dated. In right lung at point of inoculation, was a small abscess, 25 

 mm. in diameter. 



The dog inoculated with tissues of guinea-pig showed little effect 

 from it, and was killed after 245 days. The only lesion found was 

 an abscess cavity 12 mm. in diameter at point of inoculation in right 

 lung, scrapings from the wall of which contained many tubercle 

 bacilli. 



Bogs. Human Material. Too Aiiimals. — One killed after 229 

 days. The only evidence of disease was the presence of numerous 

 minute nodules on the pleural surfaces of both lungs, and a few on 

 the pericardium. The lungs were normal otherwise. 



The second dog began to cough after six weeks, lost flesh rapidly 

 and died on the sixty-third day. Both pleurae contained six ounces 

 of sanguinolent pus. The lungs were the seat of an extensive miliary 

 tuberculosis, and at point of inoculation in right lung was an ab- 



