No. 6. DEPARTMENT OF AGRICULTURE. 109 



2. A licifer, elev«^n months old, whicli received two feeding^s with 

 an interval of two davs, the material being taken in j^art from the 

 lung of a child with acute miliary tuberculosis and in part from 

 the lung of an adult with a marked chronic phthisis with caseation. 

 The animal soon became sick, and during life tuberculoisis could be 

 detected. The submaxillary ganglion on the right side became en- 

 larged about the fifteenth day, and increased steadily until the ani- 

 mal was killed on the fifty-ninth da}-. The intestinal tract was only 

 slightly involved, but the ganglia related to the first portion of the 

 digestive tract showed marked lesions. The right submaxillary and 

 the retropharyngeal glands were considerably enlarged and showed 

 a typical tuberculous witih some calcification. The principal lesions 

 were found in the thoracic cavity. In the lung were a dozen dissem- 

 inated foci mostly superficial, most of which showed caseous points 

 on section. Microscoincal examination showed them to be made 

 up of a great quantity of lymphoid cells, with some giant cells. In 

 the neighborhood of these masses and also in areas far from them 

 wcr€- found diffuse tubercles developing into the alveolar tissue, as 

 well as in the perivascular and peribronchial connective tissue. 

 These young lesions siiowed exactly the same histologic structures as 

 the larger ones. The bronchial and mediastinal glands were also 

 markedly involved. 



3. A young bull, about ten months old, which received two feedings 

 on two consecutive days, composed of an emulsion made from the 

 lung of two persons who had died of chronic phthisis (caseous pneu- 

 monia). After a diarrhea, which lasted several days, the animal 

 showed marked illness, and lost flesh. It soon began to couglh, and 

 so marked were the symptoms that it was slaughtered on the thirty- 

 four ih day. In the small intestine there was a marked eruption of 

 tubercles extending from about the second portion of the jejunum 

 to the end of the ileum. In certain portions the mucous membrane 

 was converted into confluent tubercles. The most interesting lesions 

 were found on the mucous membrane of the respiratory tract. In 

 the larynx and the upper part of the trachea were found masses of 

 gray granulations, a few of which were red and ulcerated. 



Second Series. — Infection hy Intravenous Injection. — A calf, three 

 months old, was inoculated into the jugular vein with 2 c.c. of an 

 emulsion made from the lung of a child with acute miliary tuber- 

 culosis. It was killed on the twentv-ninth dav. The lesions were 

 confined to the chest, the bronchial and mediastinal ganglia show- 

 ing the most marked dhanges. In the lung, on section, there were 

 found well-marked gray granulations accumulated in the interior or 

 around the small bronchi, which they sometimes occluded entirely. 

 Thi^ was well seen with the naked 3ve, but was better demonstrated 

 in microscopical sections. 



